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化疗药物治疗双原发肿瘤继发急性白血病1例及文献复习

杨喜晶,  周福平,  张迁,  钱其军

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杨喜晶, 周福平, 张迁, 钱其军. 化疗药物治疗双原发肿瘤继发急性白血病1例及文献复习[J]. 药学实践与服务, 2015, 33(5): 453-456. doi: 10.3969/j.issn.1006-0111.2015.05.020
引用本文: 杨喜晶, 周福平, 张迁, 钱其军. 化疗药物治疗双原发肿瘤继发急性白血病1例及文献复习[J]. 药学实践与服务, 2015, 33(5): 453-456. doi: 10.3969/j.issn.1006-0111.2015.05.020
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YANG Xijing, ZHOU Fuping, ZHANG Qian, QIAN Qijun. One case of double primary tumors with secondary acute leukemia induced by chemotherapy drugs and literature review[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 453-456. doi: 10.3969/j.issn.1006-0111.2015.05.020
Citation: YANG Xijing, ZHOU Fuping, ZHANG Qian, QIAN Qijun. One case of double primary tumors with secondary acute leukemia induced by chemotherapy drugs and literature review[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 453-456. doi: 10.3969/j.issn.1006-0111.2015.05.020
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化疗药物治疗双原发肿瘤继发急性白血病1例及文献复习

doi: 10.3969/j.issn.1006-0111.2015.05.020

  • 东方肝胆外科医院肿瘤生物治疗科, 上海 200438

One case of double primary tumors with secondary acute leukemia induced by chemotherapy drugs and literature review

  • Department of Biotherapy, Eastern Hepatobiliary Surgical Hospital, Shanghai 200438, China

  • 摘要: 近年来,随着化疗的大量开展,继发性白血病发病率逐年升高,笔者报道1例卵巢癌并发乳腺癌患者经化疗、放疗后出现急性粒-单细胞白血病,从初次化疗至诊断急性白血病的时间为37个月,起病急、生存期短。文献报道烷化剂、拓扑异构酶I抑制剂、铂类均易诱发继发性白血病。造血干细胞移植可降低病死率、延长无进展生存期。
    Abstract: In recent years, with a large number of chemotherapy development, the incidence of secondary leukemia increased year by year,an acute myelomonocytic leukemia after chemotherapy and radiotherapy in 1 case of ovarian cancer and breast cancer was reported. The time from first chemotherapy to acute leukemia onset was 37 months. This patient had rapid onset and short survival period. Reports in the literature suggested that alkylating agents, topoisomerase I inhibitors, platinum were all easy to induce secondary leukemia. Hematopoietic stem cell transplantation coud reduce mortality and prolong progression free survival.
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    [2] Leone G,Voso MT,Sica S, et al, Therapy related leukemias: susceptibility, prevention and treatment[J]. Leuk Lymphoma, 2001,41 (3-4): 255-276.
    [3] 肖志坚,都玉书.继发性白血病的研究现况[J].中华血液学杂志,2001,22(11):613-616.
    [4] Markman M. Chronic myelocytic leukemia as a secondary malignant condition in a patient receiving prolonged chemotherapy for ovarian carcinoma[J]. West J Med,1985,143 (2): 243.
    [5] Atichartakarn V, Punyammalee B, Nitiyanant P. Therapy related acute non-lymphocytic leukemia: report of 4 cases[J].Southeast Asian J Trop Med Public Health,1985, 16(3):421-430.
    [6] 夏忠军.卵巢癌化疗的继发性白血病[J].国际内科学杂志,1991,2(3):22-24.
    [7] Chambers SK, Chopyk RL, Chambers JT, et al, Development of leukemia after doxorubicin and cisplatin treatment for ovarian cancer[J]. Cancer, 1989,64 (12): 2459-2461.
    [8] Yokoyama Y, Futagami M, Fukushi Y, et al, Secondary acute nonlymphocytic leukemia following successful chemotherapy combining cisplatin, doxorubicin and cyclophosphamide for stage IV epithelial ovarian cancer[J]. Arch Gynecol Obstet,2000,263 (4): 206-207.
    [9] Travis LB, Holowaty EJ, Bergfeldt K, et al, Risk of leukemia after platinum-based chemotherapy for ovarian cancer[J]. N Engl J Med, 1999,340 (5): 351-357.
    [10] Yeasmin S, Nakayama K, Ishibashi M, et al, Therapy-related myelodysplasia and acute myeloid leukemia following paclitaxel-and carboplatin-based chemotherapy in an ovarian cancer patient: a case report and literature review[J]. Int J Gynecol Cancer, 2008,18 (6): 1371-1376.
    [11] Ishikawa M, Nakayama K, Rahman MT, et al, Therapy-related myelodysplastic syndrome and acute myeloid leukemia following chemotherapy (paclitaxel and carboplatin) and radiation therapy in ovarian cancer: a case report[J]. Eur J Gynaecol Oncol,2014,35 (4): 443-448.
    [12] Vay A, Kumar S, Seward S, et al, Therapy-related myeloid leukemia after treatment for epithelial ovarian carcinoma: an epidemiological analysis[J]. Gynecol Oncol,2011,123 (3): 456-460.
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  • 收稿日期:  2015-01-12
  • 修回日期:  2015-04-28

化疗药物治疗双原发肿瘤继发急性白血病1例及文献复习

doi: 10.3969/j.issn.1006-0111.2015.05.020
  • 东方肝胆外科医院肿瘤生物治疗科, 上海 200438
  • 收稿日期: 2015-01-12
  • 修回日期: 2015-04-28

摘要: 近年来,随着化疗的大量开展,继发性白血病发病率逐年升高,笔者报道1例卵巢癌并发乳腺癌患者经化疗、放疗后出现急性粒-单细胞白血病,从初次化疗至诊断急性白血病的时间为37个月,起病急、生存期短。文献报道烷化剂、拓扑异构酶I抑制剂、铂类均易诱发继发性白血病。造血干细胞移植可降低病死率、延长无进展生存期。

English Abstract

杨喜晶, 周福平, 张迁, 钱其军. 化疗药物治疗双原发肿瘤继发急性白血病1例及文献复习[J]. 药学实践与服务, 2015, 33(5): 453-456. doi: 10.3969/j.issn.1006-0111.2015.05.020
引用本文: 杨喜晶, 周福平, 张迁, 钱其军. 化疗药物治疗双原发肿瘤继发急性白血病1例及文献复习[J]. 药学实践与服务, 2015, 33(5): 453-456. doi: 10.3969/j.issn.1006-0111.2015.05.020
shu
YANG Xijing, ZHOU Fuping, ZHANG Qian, QIAN Qijun. One case of double primary tumors with secondary acute leukemia induced by chemotherapy drugs and literature review[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 453-456. doi: 10.3969/j.issn.1006-0111.2015.05.020
Citation: YANG Xijing, ZHOU Fuping, ZHANG Qian, QIAN Qijun. One case of double primary tumors with secondary acute leukemia induced by chemotherapy drugs and literature review[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 453-456. doi: 10.3969/j.issn.1006-0111.2015.05.020
shu

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