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丹参素及其衍生物心血管作用机制的研究进展

焦育强 刘文斌 袁夏 姜玉 田霖 金磊 张川

焦育强, 刘文斌, 袁夏, 姜玉, 田霖, 金磊, 张川. 丹参素及其衍生物心血管作用机制的研究进展[J]. 药学实践与服务, 2015, 33(5): 389-391,405. doi: 10.3969/j.issn.1006-0111.2015.05.002
引用本文: 焦育强, 刘文斌, 袁夏, 姜玉, 田霖, 金磊, 张川. 丹参素及其衍生物心血管作用机制的研究进展[J]. 药学实践与服务, 2015, 33(5): 389-391,405. doi: 10.3969/j.issn.1006-0111.2015.05.002
JIAO Yuqiang, LIU Wenbin, YUAN Xia, JIANG Yu, TIAN Lin, JIN Lei, ZHANG Chuan. Study progress of Danshensu and its derivatives in cardiovascular mechanism[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 389-391,405. doi: 10.3969/j.issn.1006-0111.2015.05.002
Citation: JIAO Yuqiang, LIU Wenbin, YUAN Xia, JIANG Yu, TIAN Lin, JIN Lei, ZHANG Chuan. Study progress of Danshensu and its derivatives in cardiovascular mechanism[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 389-391,405. doi: 10.3969/j.issn.1006-0111.2015.05.002

丹参素及其衍生物心血管作用机制的研究进展

doi: 10.3969/j.issn.1006-0111.2015.05.002

Study progress of Danshensu and its derivatives in cardiovascular mechanism

  • 摘要: 丹参素是丹参的主要水溶性活性成分之一,具有多种药理活性,尤其对心血管系统具有明显的保护作用。笔者从抗凋亡、抗氧化、抑制钙超载和作用于炎症反应通路等方面,对丹参素及其衍生物心血管药理作用机制进行综述。
  • [1] Wu L, Qiao H, Li Y, et al. Protective roles of puerarin and Danshensu on acute ischemic myocardial injury in rats[J]. Phytomedicine, 2007, 14(10): 652-658.
    [2] Yin Y, Guan Y, Duan JL, et al. Cardioprotective effect of Danshensu against myocardial ischemia/reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation[J].Eur J Pharmacol, 2013, 669(1): 219-226.
    [3] Lam FFY, Yeung JHK, Chan KM, et al. Relaxant effects of danshen aqueous extract and its constituent danshensu on rat oronary artery are mediated by inhibition of calcium channels[J].Vascul Pharmacol, 2007, 46(4): 271-277.
    [4] Tang YQ, Wang MH, Le XY, et al. Antioxidant and cardioprotective effects of Danshensu (3-(3,4-dih-ydroxyph-enyl)-2-hydroxy-propanoic acid from salvia miltiorrhiza) on isoproterenol-induced myocardial hypertrophy in rats[J].Phytomedicine, 2011, 18(12): 1024-1030.
    [5] Le XY, Chen CL, Ma L, et al. Effects of Danshensu on the incidence of ischemia-reperfusioninduced arrhythmia in hypertrophy rat heart[J].Chin J Nat Med, 2008, 6(6): 461-465.
    [6] Wang F, Liu YY, Liu LY, et al. The attenuation effect of 3,4-dihydroxy-phenyl lactic acid and salvianolic acid B on venular thrombosis induced in rat mesentery by photochemical reaction[J].Clin Hemorheol Microcirc, 2009, 42(1): 7-18.
    [7] Tang YQ, Wang MH, Chen CL, et al. Cardiovascular protection with Danshensu in spontaneously hypertensive rats[J].Biol Pharm Bull, 2011, 34(10): 1596-1601.
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    [10] 郭自强, 王硕仁, 朱陵群, 等. 丹参素和川芎嗪对血管紧张素Ⅱ诱导乳鼠心肌细胞凋亡的影响[J].中西医结合脑血管病杂志, 2006, 4(6): 494-495.
    [11] Liam P, Grant N, Caitlin C, et al. Anti-apoptosis and cell survival: a review[J].Biochim Biophys Acta, 2011, 1813(1): 238-259.
    [12] Jia YL, Dong XY, Zhou PF, et al. The synthesis and biological evaluation of novel Danshensu-ecysteine analog conjugates as cardiovascular-protective agents[J].Eur J Med Chem, 2012, 55: 176-187.
    [13] Zhao GR,Zhang HM,Ye TX,et al.Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B[J]. Food Chem Toxicol,2008,46(1):73-81.
    [14] 陆文铨, 张国强, 陈大贵, 等. 丹参素对大鼠急性心肌缺血的保护作用[J].药学实践杂志, 2010, 28(4): 279-282.
    [15] 王胜男, 叶 攀, 敖杰男. 丹参素对过氧化氢所致人脐静脉内层细胞损伤的保护作用研究[J].时珍国医国药, 2011, 22(1): 66-69.
    [16] 童海达, 王佳茗, 宋 英. Keapl-Nrf2-ARE在机体氧化应激损伤中的防御作用[J].癌变畸变突变, 2013, 25(1): 71-75.
    [17] 李 冰. Nrf2信号通路及其分子调控机制[J].国外医学(医学地理分册), 2012, 33(3): 148-150.
    [18] Cui GZ, Shan LC, Hung MW, et al. A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways[J].Int J Cardiol, 2013,168(2):1349-1359.
    [19] 顾 明, 吴兴文, 李芳萍, 等. 丹参素对大鼠心室肌动作电位、L-型钙电流和ATP敏感性钾电流的作用[J].中国临床药学杂志, 2010, 19(1): 1-5.
    [20] 钱为民, 邓春玉, 薛玉梅, 等. 丹参素对豚鼠心室肌细胞L-型钙通道的影响[J].岭南心血管病杂志, 2002, 8(4): 276-278.
    [21] 赵艳威, 谢文利, 孙文军, 等. 丹参素对豚鼠心室肌细胞钠电流的影响[J].武警医学院学报, 2005, 14(4): 256-257.
    [22] 张 洁, 曾晓荣, 杨 艳, 等. 丹参素对猪冠脉平滑肌细胞钙激活钾通道的作用[J].基础医学与临床, 2005, 25(11): 1054-1057.
    [23] 董六一, 陈志武. 心肌缺血/再灌注损伤与炎症反应[J].中国临床药理学与治疗学, 2008, 13(5): 582-588.
    [24] Guan Y, Yin Y, Zhu YR, et al. Dissection of mechanisms of a Chinese medicinal formula Danhong injection therapy for myocardia ischemia reperfusion injury in vivo and in vitro[J].Evid Based Complement Alternat Med, 2013,2013(2):1-124.
    [25] 权 伟, 周 丹, 郭 超, 等. 丹参素钠通过抑制炎症反应对心肌缺血再灌注损伤的保护作用[J].中南药学, 2012, 12: 885-888.
    [26] 姜开余, 顾振纶, 阮长耿. 丹参素对CD11b、P-selectin、ICAM-1、VCAM-1、E-selectin表达的影响[J].中国药理学通报, 2000, 16(6): 682-685.
    [27] Ridder DA, Schwaninger M. NF-κB signaling in cerebral ischemia[J].Neuroscience, 2009, 158(3): 995-1006.
    [28] Liu XH, Pan LL, Jia YL, et al. A novel compound DSC suppresses lipopolysaccharide-induced inflammatory responses by inhibition of Akt/NF-κB signallingn in macrophages[J].Eur J Pharmacol, 2013, 708(1): 8-13.
    [29] Xie XN, Wang SX, Xiao L, et al. DBZ blocks LPS-induced monocyte activation and foam cell formation via inhibiting nuclear factor-κB[J].Cell Physiol Biochem, 2011, 28(4): 649-662.
    [30] Yang GD, Zhang H, Lin R, et al. Down-regulation of CD40 gene expression and inhibition of apoptosis with Danshensu in endothelial cells[J].Basic Clin Pharmacol Toxicol, 2009, 104(2): 87-92.
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  • 收稿日期:  2013-12-23
  • 修回日期:  2014-04-18

丹参素及其衍生物心血管作用机制的研究进展

doi: 10.3969/j.issn.1006-0111.2015.05.002

摘要: 丹参素是丹参的主要水溶性活性成分之一,具有多种药理活性,尤其对心血管系统具有明显的保护作用。笔者从抗凋亡、抗氧化、抑制钙超载和作用于炎症反应通路等方面,对丹参素及其衍生物心血管药理作用机制进行综述。

English Abstract

焦育强, 刘文斌, 袁夏, 姜玉, 田霖, 金磊, 张川. 丹参素及其衍生物心血管作用机制的研究进展[J]. 药学实践与服务, 2015, 33(5): 389-391,405. doi: 10.3969/j.issn.1006-0111.2015.05.002
引用本文: 焦育强, 刘文斌, 袁夏, 姜玉, 田霖, 金磊, 张川. 丹参素及其衍生物心血管作用机制的研究进展[J]. 药学实践与服务, 2015, 33(5): 389-391,405. doi: 10.3969/j.issn.1006-0111.2015.05.002
JIAO Yuqiang, LIU Wenbin, YUAN Xia, JIANG Yu, TIAN Lin, JIN Lei, ZHANG Chuan. Study progress of Danshensu and its derivatives in cardiovascular mechanism[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 389-391,405. doi: 10.3969/j.issn.1006-0111.2015.05.002
Citation: JIAO Yuqiang, LIU Wenbin, YUAN Xia, JIANG Yu, TIAN Lin, JIN Lei, ZHANG Chuan. Study progress of Danshensu and its derivatives in cardiovascular mechanism[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 389-391,405. doi: 10.3969/j.issn.1006-0111.2015.05.002
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