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纳米结构脂质载体促进难溶性药物口服吸收机制的研究进展

刘建清,  张晶,  赵佳丽,  宋洪涛

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文章导航 > 药学实践与服务  > 2014 >  32(4): 254-256,277
刘建清, 张晶, 赵佳丽, 宋洪涛. 纳米结构脂质载体促进难溶性药物口服吸收机制的研究进展[J]. 药学实践与服务, 2014, 32(4): 254-256,277. doi: 10.3969/j.issn.1006-0111.2014.04.004
引用本文: 刘建清, 张晶, 赵佳丽, 宋洪涛. 纳米结构脂质载体促进难溶性药物口服吸收机制的研究进展[J]. 药学实践与服务, 2014, 32(4): 254-256,277. doi: 10.3969/j.issn.1006-0111.2014.04.004
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LIU Jianqing, ZHANG Jing, ZHAO Jiali, SONG Hongtao. Mechanism of nanostructured lipid carriers in promotion of absorption of poorly soluble drugs[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 254-256,277. doi: 10.3969/j.issn.1006-0111.2014.04.004
Citation: LIU Jianqing, ZHANG Jing, ZHAO Jiali, SONG Hongtao. Mechanism of nanostructured lipid carriers in promotion of absorption of poorly soluble drugs[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 254-256,277. doi: 10.3969/j.issn.1006-0111.2014.04.004
shu

纳米结构脂质载体促进难溶性药物口服吸收机制的研究进展

doi: 10.3969/j.issn.1006-0111.2014.04.004
  • 1.

    南京军区福州总医院药学科, 福建 福州 350025;福建医科大学药学院, 福建 福州 350108

  • 2.

    南京军区福州总医院药学科, 福建 福州 350025

  • 3.

    南京军区福州总医院药学科, 福建 福州 350025;厦门大学医学院, 福建 厦门 361005

Mechanism of nanostructured lipid carriers in promotion of absorption of poorly soluble drugs

  • 1.

    Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China;School of Pharmacy, Fujian Medical University, Fuzhou 350108, China

  • 2.

    Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China

  • 3.

    Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China;School of Medicine, Xiamen University, Xiamen 361005, China

  • 摘要: 纳米结构脂质载体(NLC)是药剂学备受关注的研究领域,作为一种性能优良的新型药物传递系统,能促进难溶性药物的口服吸收。探讨并总结纳米结构脂质载体促进难溶性药物口服吸收的机制。
    Abstract: Objective Nano-structured lipid carriers (NLC) is a concerned research area in pharmaceutics, which as a novel drug delivery system to promote oral absorption of poorly soluble drugs.The literatures were reviewed to explore and summarize the mechanism that nano-structured lipid carriers in promotion of the absorption of poorly soluble drugs.
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    [12] Thomson AB, Schoeller C, Keelan M, et al. Lipid absorption: passing through theunstirred layers, brush-border membrane, and beyond[J]. Can J Physiol Pharmacol, 1993, 71 (8):531-555.
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    [14] Müller RH,Runge S,Ravelli V,et al.Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN) versus drug nanocrystals[J].Int J Pharm,2006,317(1):82-89.
    [15] Elgart A, Cherniakov I, Aldouby Y, et al.Improved oral bioavailability of BCS class 2 compounds by self nano-emulsifying drug delivery systems (SNEDDS):the underlying mechanisms for amiodarone and talinolol[J].Pharm Res,2013(5):212-215.
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    [18] Mu HL, Hφy CE. The digestion of dietary triacylglycerols[J]. Prog Lipid Res, 2004, 43(2):105-133.
    [19] Ravi D, Hywel DW, Dallas B, et al. In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion products[J]. Int J Pharm,2013,441(1):323-333.
    [20] Hans B, Jenneke P,Ruud J, et al. Characterization of translocation of silver nanoparticles and effects on whole-genome gene expression using an in vitro intestinal epithelium coculture model[J]. ACS Nano, 2011, 5 (5): 4091-4103.
    [21] Takeuchi H, Yamamoto H, Kawashima Y, et al. Mucoadhesive nanoparticulate systems for peptide drug delivery[J]. Adv Drug Deliv Rev,2001,47(1):39.
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  • 收稿日期:  2013-05-28
  • 修回日期:  2013-11-05

纳米结构脂质载体促进难溶性药物口服吸收机制的研究进展

doi: 10.3969/j.issn.1006-0111.2014.04.004
  • 1. 南京军区福州总医院药学科, 福建 福州 350025;福建医科大学药学院, 福建 福州 350108
  • 2. 南京军区福州总医院药学科, 福建 福州 350025
  • 3. 南京军区福州总医院药学科, 福建 福州 350025;厦门大学医学院, 福建 厦门 361005
  • 收稿日期: 2013-05-28
  • 修回日期: 2013-11-05

摘要: 纳米结构脂质载体(NLC)是药剂学备受关注的研究领域,作为一种性能优良的新型药物传递系统,能促进难溶性药物的口服吸收。探讨并总结纳米结构脂质载体促进难溶性药物口服吸收的机制。

English Abstract

刘建清, 张晶, 赵佳丽, 宋洪涛. 纳米结构脂质载体促进难溶性药物口服吸收机制的研究进展[J]. 药学实践与服务, 2014, 32(4): 254-256,277. doi: 10.3969/j.issn.1006-0111.2014.04.004
引用本文: 刘建清, 张晶, 赵佳丽, 宋洪涛. 纳米结构脂质载体促进难溶性药物口服吸收机制的研究进展[J]. 药学实践与服务, 2014, 32(4): 254-256,277. doi: 10.3969/j.issn.1006-0111.2014.04.004
shu
LIU Jianqing, ZHANG Jing, ZHAO Jiali, SONG Hongtao. Mechanism of nanostructured lipid carriers in promotion of absorption of poorly soluble drugs[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 254-256,277. doi: 10.3969/j.issn.1006-0111.2014.04.004
Citation: LIU Jianqing, ZHANG Jing, ZHAO Jiali, SONG Hongtao. Mechanism of nanostructured lipid carriers in promotion of absorption of poorly soluble drugs[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 254-256,277. doi: 10.3969/j.issn.1006-0111.2014.04.004
shu

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