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低氧诱导因子-1的病理生理及相关药物研究进展

冯世杰,  马秀娟,  宗英,  毛煜,  张晓冬,  弓雪莲,  张晓芳,  陆国才

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文章导航 > 药学实践与服务  > 2014 >  32(3): 161-166
冯世杰, 马秀娟, 宗英, 毛煜, 张晓冬, 弓雪莲, 张晓芳, 陆国才. 低氧诱导因子-1的病理生理及相关药物研究进展[J]. 药学实践与服务, 2014, 32(3): 161-166. doi: 10.3969/j.issn.1006-0111.2014.03.001
引用本文: 冯世杰, 马秀娟, 宗英, 毛煜, 张晓冬, 弓雪莲, 张晓芳, 陆国才. 低氧诱导因子-1的病理生理及相关药物研究进展[J]. 药学实践与服务, 2014, 32(3): 161-166. doi: 10.3969/j.issn.1006-0111.2014.03.001
shu
FENG Shijie, MA Xiujuan, ZONG Ying, MAO Yu, ZHANG Xiaodong, GONG Xuelian, ZHANG Xiaofang, LU Guocai. Progress in pathophysiology and related drug development of hypoxia-inducible factor-1[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 161-166. doi: 10.3969/j.issn.1006-0111.2014.03.001
Citation: FENG Shijie, MA Xiujuan, ZONG Ying, MAO Yu, ZHANG Xiaodong, GONG Xuelian, ZHANG Xiaofang, LU Guocai. Progress in pathophysiology and related drug development of hypoxia-inducible factor-1[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 161-166. doi: 10.3969/j.issn.1006-0111.2014.03.001
shu

低氧诱导因子-1的病理生理及相关药物研究进展

doi: 10.3969/j.issn.1006-0111.2014.03.001

  • 第二军医大学卫生毒理学教研室, 上海 200433

基金项目: 科技部重大专项"重大新药创制"(2010ZXG0900X-005),上海市公共卫生重点实验室建设计划(12GWZX0501).

Progress in pathophysiology and related drug development of hypoxia-inducible factor-1

  • Department of Health Toxicology, Second Military Medical University, Shanghai 200433, China

  • 摘要: 低氧诱导因子-1(hypoxia-inducible factors, HIF-1)是介导哺乳动物和人体细胞低氧适应性反应的主要核转录因子,是专一调节氧稳态的关键物质。HIF-1对胚胎的正常发育,软骨及骨的形成等多种生理过程起保护及促进作用,也与肿瘤、糖尿病及其并发症等多种缺血低氧性疾病密切相关。HIF-1在这些疾病中的分子机制已成为目前的研究热点,笔者就HIF-1的结构特征、调控机制、生物学效用及在药物研发等方面进行综述。
    Abstract: Hypoxia-inducible factor-1 (HIF-1) is a critical nuclear transcriptional factor mediating cell adaptive response to hypoxia in mammalian and human. It is the key mediator which modulates oxygen homeostasis exclusively. In the one hand, HIF-1 can protect and promote kinds of physiological processes, such as embryo normal development, cartilage and bone formation. In the other hand, it is also involved in lots of human deceases which is caused by ischemia and hypoxia, such as tumor, diabetes and its complications. The molecular mechanisms of HIF-1 involved in these diseases have become a research hotspot and such studies will provide the new therapeutic means for these diseases, recent new drug researches have been focused on HIF-1 related signal pathway inhibitors, HIF-1 activity inhibitors, HIF-1 targeted therapy, etc.
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    [15] Cai Z, Zhong H, Bosch-Marce M, et al. Complete loss of ischaemic preconditioning induced cardioprotection in mice with partial deficiency of HIF-1α[J]. Cardiovas Res, 2008, 77(3): 463-470.
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    [19] Luo W, Hu H, Chang R, et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1[J].Cell, 2011, 145(5): 732-744.
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  • 收稿日期:  2013-03-19
  • 修回日期:  2013-10-18

低氧诱导因子-1的病理生理及相关药物研究进展

doi: 10.3969/j.issn.1006-0111.2014.03.001
  • 第二军医大学卫生毒理学教研室, 上海 200433
    • 基金项目:  科技部重大专项"重大新药创制"(2010ZXG0900X-005),上海市公共卫生重点实验室建设计划(12GWZX0501).
  • 收稿日期: 2013-03-19
  • 修回日期: 2013-10-18

摘要: 低氧诱导因子-1(hypoxia-inducible factors, HIF-1)是介导哺乳动物和人体细胞低氧适应性反应的主要核转录因子,是专一调节氧稳态的关键物质。HIF-1对胚胎的正常发育,软骨及骨的形成等多种生理过程起保护及促进作用,也与肿瘤、糖尿病及其并发症等多种缺血低氧性疾病密切相关。HIF-1在这些疾病中的分子机制已成为目前的研究热点,笔者就HIF-1的结构特征、调控机制、生物学效用及在药物研发等方面进行综述。

English Abstract

冯世杰, 马秀娟, 宗英, 毛煜, 张晓冬, 弓雪莲, 张晓芳, 陆国才. 低氧诱导因子-1的病理生理及相关药物研究进展[J]. 药学实践与服务, 2014, 32(3): 161-166. doi: 10.3969/j.issn.1006-0111.2014.03.001
引用本文: 冯世杰, 马秀娟, 宗英, 毛煜, 张晓冬, 弓雪莲, 张晓芳, 陆国才. 低氧诱导因子-1的病理生理及相关药物研究进展[J]. 药学实践与服务, 2014, 32(3): 161-166. doi: 10.3969/j.issn.1006-0111.2014.03.001
shu
FENG Shijie, MA Xiujuan, ZONG Ying, MAO Yu, ZHANG Xiaodong, GONG Xuelian, ZHANG Xiaofang, LU Guocai. Progress in pathophysiology and related drug development of hypoxia-inducible factor-1[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 161-166. doi: 10.3969/j.issn.1006-0111.2014.03.001
Citation: FENG Shijie, MA Xiujuan, ZONG Ying, MAO Yu, ZHANG Xiaodong, GONG Xuelian, ZHANG Xiaofang, LU Guocai. Progress in pathophysiology and related drug development of hypoxia-inducible factor-1[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 161-166. doi: 10.3969/j.issn.1006-0111.2014.03.001
shu

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