摘要:
目的 了解精神科住院患者精神药物临床应用状况,为促进临床合理用药提供依据。 方法 采用横断面调查方法,调查1天精神科住院患者精神药物使用情况。 结果 住院患者总体平均用药品种数为3.51种;其中精神药物平均用药品种数为2.09种,联合用药比率为74.15%。抗精神病药使用前五位的依次是:利培酮、喹硫平、阿立哌唑、奥氮平、氯丙嗪,抗抑郁药使用前五位的依次是:文拉法辛、度洛西汀、帕罗西汀、米氮平、氟伏沙明,均以单一用药为主,新型药物已成为临床治疗中的一线药物。苯二氮类使用率为9.52%,心境稳定剂使用率为19.73%,苯海索使用率为30.61%。 结论 调研的精神科用药总体合理,但在伴有其他疾病患者的药物选用、抗抑郁药的联合使用、苯海索适应证掌握等方面也存在一些不合理之处,仍需进一步规范。
Abstract:
Objective To study the clinical application of psychotropic agents for psychiatric patients in our hospital and provide the basis for promoting rational clinical usage of drugs. Methods A cross-sectional survey method was used to survey the neuroleptics use of psychiatric inpatients in one day. Results The total average of drug kind for patients was 3.51. The average of psychotropic agent's kind was 2.09, and the combination therapy ratio was 74.15%. The top five antipsychotic drugs being used were risperidone, quetipine, aripiprazole, olanzapine and chlorpromazine. The top five antidepressant being used were venlafaxine, duloxetine, paroxetine, mirtazapine and fluvoxamine. The patients mainly used single medicines and new drugs had become the first-line medicines in clinical treatment. The utilization rate of benzodiazepines was 9.52%, utilization rate of mood stabilizer was 19.73% and utilization rate of trihexyphenidyl was 30.61%. Conclusion The usage of medicines in psychiatric department of our hospital was rational on the whole. But there were also some loopholes in other aspects, such as combination used of antidepressant drugs, trihexyphenidyl indications controlling, drug selection accompanied by other disease, which should still need to be strengthened.
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