Comparison of two different methods for preparation inclusion compound of β-cyclodextrin with Peppermint Oil
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摘要: 目的 比较饱和水溶液法和超声法制备薄荷油β-环糊精包合物的工艺。 方法 选用适量薄荷药材,提取薄荷油,分别用饱和水溶液法和超声法制备薄荷油β-环糊精包合物。 结果 与超声法相比,饱和水溶液法制备薄荷油β-环糊精包合率和包合物的收率均较高;并通过正交试验确定了饱和水溶液法最佳包合工艺为薄荷油(ml):β-环糊精(g)为1:5、搅拌时间为1 h、包合温度45℃,β-环糊精(g):水(ml)为1:10。 结论 优选的饱和水溶液法包合工艺合理、结果较好,并且操作更为简便。
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关键词:
- 薄荷油β-环糊精包合物 /
- 饱和水溶液法 /
- 超声法
Abstract: Objective To compare the methods of saturated water solution and ultrasonic for preparation inclusion compound of β-cyclodextrin with peppermint oil. Methods After extraction of peppermint oil, the inclusion compound of β-cyclodextrin with peppermint oil was prepared by saturated water solution method and ultrasonic method. Results The better inclusion method was saturated water solution with higher inclusion rate and yield of inclusion compound. And the optimum inclusion conditions were as follows:peppermint oil(ml):β-cyclodextrin(g)=1:5, stirring for 1 hour, 45℃, β-cyclodextrin(g):water(ml)=1:10. Conclusion The better inclusion method was saturated water solution which was reasonable and convenient. -
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