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老年药物性肝损害的临床特点

唐险峰,  孙杰,  路明珠

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文章导航 > 药学实践与服务  > 2013 >  31(1): 22-23,66
唐险峰, 孙杰, 路明珠. 老年药物性肝损害的临床特点[J]. 药学实践与服务, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006
引用本文: 唐险峰, 孙杰, 路明珠. 老年药物性肝损害的临床特点[J]. 药学实践与服务, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006
shu
TANG Xian-feng, SUN Jie, LU Ming-zhu. The clinical features of drug-induced liver injury in elderly[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006
Citation: TANG Xian-feng, SUN Jie, LU Ming-zhu. The clinical features of drug-induced liver injury in elderly[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006
shu

老年药物性肝损害的临床特点

doi: 10.3969/j.issn.1006-0111.2013.01.006
  • 1.

    总后上海干休所, 上海 200437

  • 2.

    第二军医大学附属长征医院药剂科, 上海 200003

The clinical features of drug-induced liver injury in elderly

  • 1.

    Shanghai Retired Cadres, General Logistics Department, Shanghai, 200437 China

  • 2.

    Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

  • 摘要: 药物引起的肝毒性是老年人肝脏疾病的重要原因,发生率是年轻人的4倍多,且类型几乎包括了所有已知的肝脏疾病。因为大多数的临床试验排除了大于75~80岁年龄组患者,有关药物副作用的报告在大于60岁年龄组中相当罕见。为此,需要进一步的临床研究,以探讨老年患者肝脏的药物副作用。本文主要综述了老年药物性肝损害的主要临床表现和诊断以及近年来常见药物(心血管药物和抗微生物药物)引起肝损伤的临床情况。
    Abstract: Drug-induced hepato-toxicity was an important reason for the liver disease in elderly,which was four times more common than in adults and might include all known liver disorders. Reports related to drug side effects were rare in people >60 years of age group since most clinical trials exclude patients >75~80 years of age. Further clinical studies should be need to investigate hepatic side effects of drugs in elderly patients. The main clinical manifestations and diagnosis of drug-induced liver injury in elderly as well as common drugs (cardiovascular drugs and anti-microbial agents) cause liver injury in clinical conditions were reviewed in this paper.
  • [1] 付 静,李志军.药物性肝病的发病机制及治疗新进展[J].天津医药,2009,37(4):333.
    [2] 王 文,于 红. 61例药物性肝病临床特点与转归分析[J].实用肝病学杂志,2008,11(3):191.
    [3] Chang CY, Schiano TD. Drug hepatotoxicity[J]. Aliment Pharmacol Ther, 2007,25:1135.
    [4] Hayes BD, Klein-Schwartz W, Barrueto Jr F. Polypharmacy and the geriatric patient[J]. Clin Geriatr Med, 2007,23: 371.
    [5] Onji M, Fujioka S, Takeuchi Y, et al. Clinical characteristics of drug-induced liver injury in the elderly[J]. Hepatol Res, 2009,39:546.
    [6] Tajiri K, Shimizu Y. Practical guidelines for diagnosis and early management of drug-induced liver injury[J]. World J Gastroenterol ,2008,14:6774.
    [7] Nathwani RA, Kaplowitz N. Drug hepatotoxicity[J]. Clin Liver Dis ,2006,10:207.
    [8] Hussaini SH, Farrington EA. Idiosyncratic drug-induced liver injury: an overview[J]. Expert Opin Drug Saf, 2007,6:673.
    [9] Taggart HM, Alderdice JM. Fatal cholestatic jaundice in elderly patients taking benoxaprofen[J]. BMJ, 1982,284:1372.
    [10] 马 琳,刘 波. 85例老年药物型肝炎患者临床分析[J]. 实用肝病杂志, 2011, 14(1):45.
    [11] 王 林,张人凤,金 鸿,等.药物性肝损害90例临床分析[J]. 临床荟萃, 2011 ,26 (2):162.
    [12] 徐列明,林庆勋.正确认识中药的肝毒性[J]. 中华肝病杂志, 2007,15(7):534.
    [13] Lucena MI, Andrade RJ, Ferna'ndez MC, et al. Determinants of the clinical expression of amoxicillin-clavulanate hepatotoxicity: a prospective series from Spain[J]. Hepatology, 2006,44:850.
    [14] Kaplowitz N. Idiosyncratic drug hepatotoxicity[J]. Nat Rev Drug Discov,2005,4:489.
    [15] Chien RN, Yang LJ, Lin PY, et al. Hepatic injury during ketoconazole therapy in patients with onychomycosis: a controlled cohort study[J]. Hepatology, 1997,25:103.
    [16] Stricker BH, Blok AP, Claas FH, et al. Hepatic injury associated with the use of nitrofurans: a clinicopathological study of 52 reported cases[J]. Hepatology, 1988,8:59.
    [17] Raúl J Andrade, Paul M, Tulkens J. Hepatic safety of antibiotics used in primary care[J]. J Antimicrob Chemother, 2011, 66: 1431.
    [18] Hagley MT, Hulisz DT, Burns CM. Hepatotoxicity associated with angiotensin-converting enzyme inhibitorset[J]. Ann Pharmacother, 1993,27:228.
    [19] Andrade RJ, Lucena MI, Ferna'ndez MC, et al. Cholestatic hepatitis related to use of irbesartan: a case report and a literature review of angiotensin II antagonist-associated hepatotoxicity[J]. Eur J Gastroenterol Hepatol, 2002,14:887.
    [20] Farmer JA, Torre-Amione G. Comparative tolerability of the HMG-CoA reductase inhibitors[J]. Drug Saf ,2000,23:197.
    [21] Laine L, Goldkind L, Curtis SP, et al. How common is diclofenac-associated liver injury? Analysis of 17,289 arthritis patients in a long-term prospective clinical trial[J]. Am J Gastroenterol, 2009,104:356.
    [22] Lewis JH, Schiff ER. Methotrexate-induced chronic liver injury: guidelines for detection and prevention[J]. Am J Gastroenterol,1988,88:1337.
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  • 收稿日期:  2012-04-25
  • 修回日期:  2012-11-12

老年药物性肝损害的临床特点

doi: 10.3969/j.issn.1006-0111.2013.01.006
  • 1. 总后上海干休所, 上海 200437
  • 2. 第二军医大学附属长征医院药剂科, 上海 200003
  • 收稿日期: 2012-04-25
  • 修回日期: 2012-11-12

摘要: 药物引起的肝毒性是老年人肝脏疾病的重要原因,发生率是年轻人的4倍多,且类型几乎包括了所有已知的肝脏疾病。因为大多数的临床试验排除了大于75~80岁年龄组患者,有关药物副作用的报告在大于60岁年龄组中相当罕见。为此,需要进一步的临床研究,以探讨老年患者肝脏的药物副作用。本文主要综述了老年药物性肝损害的主要临床表现和诊断以及近年来常见药物(心血管药物和抗微生物药物)引起肝损伤的临床情况。

English Abstract

唐险峰, 孙杰, 路明珠. 老年药物性肝损害的临床特点[J]. 药学实践与服务, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006
引用本文: 唐险峰, 孙杰, 路明珠. 老年药物性肝损害的临床特点[J]. 药学实践与服务, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006
shu
TANG Xian-feng, SUN Jie, LU Ming-zhu. The clinical features of drug-induced liver injury in elderly[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006
Citation: TANG Xian-feng, SUN Jie, LU Ming-zhu. The clinical features of drug-induced liver injury in elderly[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006
shu

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