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他汀类药物多效药理作用及其机制研究进展

赵心彬,  倪敏,  陶霞

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文章导航 > 药学实践与服务  > 2013 >  31(1): 19-21
赵心彬, 倪敏, 陶霞. 他汀类药物多效药理作用及其机制研究进展[J]. 药学实践与服务, 2013, 31(1): 19-21. doi: 10.3969/j.issn.1006-0111.2013.01.005
引用本文: 赵心彬, 倪敏, 陶霞. 他汀类药物多效药理作用及其机制研究进展[J]. 药学实践与服务, 2013, 31(1): 19-21. doi: 10.3969/j.issn.1006-0111.2013.01.005
shu
ZHAO Xin-bin, NI Min, TAO Xia. Progress on the multiple pharmacological activity and mechanism of statins[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 19-21. doi: 10.3969/j.issn.1006-0111.2013.01.005
Citation: ZHAO Xin-bin, NI Min, TAO Xia. Progress on the multiple pharmacological activity and mechanism of statins[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 19-21. doi: 10.3969/j.issn.1006-0111.2013.01.005
shu

他汀类药物多效药理作用及其机制研究进展

doi: 10.3969/j.issn.1006-0111.2013.01.005

  • 第二军医大学长征医院药学部, 上海 200003

Progress on the multiple pharmacological activity and mechanism of statins

  • Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

  • 摘要: 他汀类是临床上治疗高胆固醇血症主要药物, 广泛应用于冠心病一级及二级预防。近年来研究表明,他汀类药物还具有降脂外的多重作用,包括改善血管内皮功能、抗炎症、抗氧化作用、稳定动脉粥样硬化和抗肿瘤作用等。本文围绕他汀类药物对血管疾病和肿瘤的作用及机制展开综述。
    Abstract: Statins were a mainstay in the treatment of hyperlipidemia and used in the primary and secondary prevention of coronary artery disease. Recent studies indicated that there were some cholesterol-independent or pleiotropic effects of statins, including improving endothelial function, decreasing oxidative stress, inhibiting inflammation, enhancing the stability of atherosclerotic plaques and used for anticancer therapy. The effects and mechanisms of statins on vascular disease and cancer were reviewed in this paper.
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    [2] Farwell WR,D'Avolio LW,Scranton RE,et al. Stains and prostate cancer diagnosis and grade in a veterans population[J].J Natl Cancer Inst, 2011, 103(11):885.
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    [9] 陈巧玲,蔡宝祥.他汀类药物防治动脉粥样硬化作用研究进展[J].药学实践杂志,2006,24(6):321.
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    [21] 王 磊,胡昌华.他汀类药物抗癌作用新机制[J].中国药学杂志,2010,45(23):1796.
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出版历程
  • 收稿日期:  2012-02-14
  • 修回日期:  2012-04-05

他汀类药物多效药理作用及其机制研究进展

doi: 10.3969/j.issn.1006-0111.2013.01.005
  • 第二军医大学长征医院药学部, 上海 200003
  • 收稿日期: 2012-02-14
  • 修回日期: 2012-04-05

摘要: 他汀类是临床上治疗高胆固醇血症主要药物, 广泛应用于冠心病一级及二级预防。近年来研究表明,他汀类药物还具有降脂外的多重作用,包括改善血管内皮功能、抗炎症、抗氧化作用、稳定动脉粥样硬化和抗肿瘤作用等。本文围绕他汀类药物对血管疾病和肿瘤的作用及机制展开综述。

English Abstract

赵心彬, 倪敏, 陶霞. 他汀类药物多效药理作用及其机制研究进展[J]. 药学实践与服务, 2013, 31(1): 19-21. doi: 10.3969/j.issn.1006-0111.2013.01.005
引用本文: 赵心彬, 倪敏, 陶霞. 他汀类药物多效药理作用及其机制研究进展[J]. 药学实践与服务, 2013, 31(1): 19-21. doi: 10.3969/j.issn.1006-0111.2013.01.005
shu
ZHAO Xin-bin, NI Min, TAO Xia. Progress on the multiple pharmacological activity and mechanism of statins[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 19-21. doi: 10.3969/j.issn.1006-0111.2013.01.005
Citation: ZHAO Xin-bin, NI Min, TAO Xia. Progress on the multiple pharmacological activity and mechanism of statins[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 19-21. doi: 10.3969/j.issn.1006-0111.2013.01.005
shu

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