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微透析与液相色谱-质谱联用在药物分析中的应用

吕狄亚,  洪战英,  娄子洋,  曹岩,  董昕,  柴逸峰

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吕狄亚, 洪战英, 娄子洋, 曹岩, 董昕, 柴逸峰. 微透析与液相色谱-质谱联用在药物分析中的应用[J]. 药学实践与服务, 2011, 29(2): 93-96,119.
引用本文: 吕狄亚, 洪战英, 娄子洋, 曹岩, 董昕, 柴逸峰. 微透析与液相色谱-质谱联用在药物分析中的应用[J]. 药学实践与服务, 2011, 29(2): 93-96,119.
shu
LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.
Citation: LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.
shu

微透析与液相色谱-质谱联用在药物分析中的应用

  • 第二军医大学药学院,上海 200433

基金项目: 国家自然科学基金资助委员会资助项目(30873196);上海市科学技术委员会科研计划项目(09dZ1975100).

Application of micro-dialysis-LC/MS in pharmaceutical analysis

  • School of Pharmacy, Second Military Medical University ,Shanghai 200433, China

  • 摘要: 目的 综述微透析与液相色谱-质谱联用技术在药物体内化学成分分析中的研究进展。 方法 参阅近几年国内外相关文献,对微透析与液相色谱-质谱联用技术在药物体内内源性物质及外源性物质中的应用进行归纳与总结。 结果与结论 微透析与液相色谱-质谱联用作为一种新型的分析技术,具有快速简便、干扰少、前处理简单等优点。此项技术在体内药物分析中得到了迅速推广和应用,特别在药代动力学研究中显示出其独特的优势,具有十分广阔的应用前景。
    Abstract: Objective To review the micro-dialysis coupled with chromatographic technologies in pharmaceutical analysis in vivo. Methods The relevant literatures were collected to make a summary of microdialysis coupled with chromatography technology in pharmaceutical analysis in vivo. Results and Conclusions As a new sampling technology, microdialysis coupled with LC-MS had advantages of high sensitive, fast, simple, less interference, and no sample preparation. This technology had been rapidly promoted and applied, especially in the pharmacokinetic-pharmacodynamic studies which had broad application prospects.
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  • 收稿日期:  2010-09-26
  • 修回日期:  2010-12-30

微透析与液相色谱-质谱联用在药物分析中的应用

  • 第二军医大学药学院,上海 200433
    • 基金项目:  国家自然科学基金资助委员会资助项目(30873196);上海市科学技术委员会科研计划项目(09dZ1975100).
  • 收稿日期: 2010-09-26
  • 修回日期: 2010-12-30

摘要: 目的 综述微透析与液相色谱-质谱联用技术在药物体内化学成分分析中的研究进展。 方法 参阅近几年国内外相关文献,对微透析与液相色谱-质谱联用技术在药物体内内源性物质及外源性物质中的应用进行归纳与总结。 结果与结论 微透析与液相色谱-质谱联用作为一种新型的分析技术,具有快速简便、干扰少、前处理简单等优点。此项技术在体内药物分析中得到了迅速推广和应用,特别在药代动力学研究中显示出其独特的优势,具有十分广阔的应用前景。

English Abstract

吕狄亚, 洪战英, 娄子洋, 曹岩, 董昕, 柴逸峰. 微透析与液相色谱-质谱联用在药物分析中的应用[J]. 药学实践与服务, 2011, 29(2): 93-96,119.
引用本文: 吕狄亚, 洪战英, 娄子洋, 曹岩, 董昕, 柴逸峰. 微透析与液相色谱-质谱联用在药物分析中的应用[J]. 药学实践与服务, 2011, 29(2): 93-96,119.
shu
LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.
Citation: LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.
shu

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