摘要:
目的: 扩大名贵药用植物番红花的药用资源,寻找可以替代传统药用部位(柱头)的新药用部位。 方法: 分别采用醋酸致小鼠扭体和二甲苯致小鼠耳肿胀药理模型,分别以吲哚关辛和地塞米松为镇痛和抗炎药效学实验的阳性对照药,观察番红花球茎、顶芽、侧芽和柱头的乙醇和水提取物的镇痛和抗炎活性。 结果: 在镇痛实验中,与空白对照组相比,顶芽醇提取物和水提取物、柱头的醇提物和水提物以及侧芽的醇提物在高剂量时(相当于2.0 g生药/kg)都具有显著的镇痛活性(P<0.05或P<0.01);球茎的醇提物和水提物、侧芽醇提取物的低剂量和中剂量以及水提物均未见有镇痛活性;在抗炎试验中,与空白对照组相比,番红花柱头醇提物和侧芽醇提物均显示出显著的抗炎活性(P<0.05或P<0.01)。顶芽醇提物在低剂量(相当于0. 75 g生药/kg)时也具有显著的抗炎活性(P<0.05)。球茎醇提取物和水提物及顶芽、侧芽和柱头的水提物对二甲苯致小鼠耳肿胀没有显著性影响。 结论: 以番红花的顶芽、侧芽替代传统药用部位柱头,分别用于镇痛和抗炎作用有潜在的应用价值,值得深入研究。
关键词:
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番红花 /
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药用部位 /
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镇痛 /
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抗炎
Abstract:
Objective: To expand new pharmacological resource,traditional plant Crocus sativus L.and to find new pharmacologi- cal active parts to take place of traditional pharmacological part,stigma. Methods: The methods of an abdominal constriction induced by acetic-acid and xylene-induced mice ear edema were used to investigate the analgesic and anti-inflammatory effects of different ex- tracts from Crocus sativus,respectively.Indomethacin and dexamethasone were used as positive control of analgesic and anti-inflamma- tory tests,respectively.The extracts included EtOH extract of corm (CE),apical bud (AE),lateral bud (LE),stigma (SE),the a- queous extract of corm (CA),apical bud (AA),lateral bud (LA),and stigma (SA).Result:In the analgesic tests,compared with negative control,the extracts from apical bud and stigma of ethanol and aqueous ( AE,SE,AA,SA) and lateral bud extract of ethanol at the dose of 2.0 g/kg showed significant (P<0.05 or P<0.01) analgesic activities.On the contrary,CE,CA,LE(at the dose of 0.75 g/kg and 1.5 g/kg),and LA showed no analgesic activities.In the anti-inflammatory tests,SE and LE of Crocus sativus showed significant anti-inflammatory effects compared with negative control.At the dose of 0.75 g/kg,the SE showed significant anti-inflam- matory effects.However,CA,AA,LA,SA and CE had no anti-inflammatory activities in the tests of xylene-induced mice ear edema. Conclusion:: The studies of apical bud and lateral bud of Crocus sativus instead of stigma of Crocus sativus on analgesic and anti-inflam- mation use worth further discussing.
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