云南狗牙花总碱的镇痛作用
Antinociceptive effects of total Ervatamia yunnansis alkaloid in mice
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摘要: 目的: 研究云南狗牙花总碱(total Ervatamia yuunansis alkaloid,TEYA)对小鼠的镇痛作用。 方法: 采用小鼠热板法,观察TEYA的镇痛作用及对吗啡的镇痛作用的影响。 结果: 与同期对照组相比,TEYA的3个剂量组均可显著提高小鼠的病阈值,镇痛效果随剂量的增加呈剂量依赖关系;同时给予TEYA(10、20mg/kg)和吗啡4mg/kg,有协同镇痛的作用;纳洛酮4mg/kg可以部分拮抗TEYA的镇痛作用。 结论: TEYA有明显的镇痛作用,其作用可能部分通过阿片受体来实现。Abstract: Objective: To observe the antinoeiceptive effect of total Ervatamia yunnansis alkaloid(TEYA) in mice. Methods: The mice hot-plate antinociceptve test was used to study the analgesic effects of TEYA and the effect on morphine in mice. Results: The three groups with different dosage of TEYA could significantly increase the pain threshold in mice and the effects increased in a dose-related manner. TEYA(10、20 mg/kg) combined with morphine 4 mg/kg had a synergic analgesic effect. The analgesic effect of TEYA could he partly blocked by naloxone 4 mg/kg. There were significantly differences between administration group and control group in the hot-plate test. Conclusion: TEYA has significant antinoeiceptive activity in hot-plate lest in mice which may be mediated by way of opioid receptors.
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Key words:
- total Ervatamia yunnansis alkaloid /
- analgesia /
- mice
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