黄芪注射液辅助治疗充血性心力衰竭的疗效及对免疫调节影响的观察

柯晓; 周宗梅; 文明; 文彩云

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黄芪注射液辅助治疗充血性心力衰竭的疗效及对免疫调节影响的观察

柯晓, 周宗梅, 文明, 文彩云

文章导航 > 药学实践与服务 > 2004 > (5): 268-270

柯晓, 周宗梅, 文明, 文彩云. 黄芪注射液辅助治疗充血性心力衰竭的疗效及对免疫调节影响的观察[J]. 药学实践与服务, 2004, (5): 268-270.

引用本文:

柯晓, 周宗梅, 文明, 文彩云. 黄芪注射液辅助治疗充血性心力衰竭的疗效及对免疫调节影响的观察[J]. 药学实践与服务, 2004, (5): 268-270.

KE Xiao, ZHOU Zong-mei, WEN Min, WEN Cai-yun. Effect of astragalus membranaceus injection on congestive heart failure and im- mune regulation[J]. Journal of Pharmaceutical Practice and Service, 2004, (5): 268-270.

Citation:

KE Xiao, ZHOU Zong-mei, WEN Min, WEN Cai-yun. Effect of astragalus membranaceus injection on congestive heart failure and im- mune regulation[J]. Journal of Pharmaceutical Practice and Service, 2004, (5): 268-270.

黄芪注射液辅助治疗充血性心力衰竭的疗效及对免疫调节影响的观察

湖北省荆州市第三人民医院, 湖北荆州 434001

Effect of astragalus membranaceus injection on congestive heart failure and im- mune regulation

The Third People Hospital of Jingzhou City, Jingzhou 434001, China

摘要: 目的探讨黄芪注射液对充血性心力衰竭(CHF)患者的疗效及对免疫调节的影响。方法对正常体检查者(体检组)和CHF组进行IgA、IgG、IgM、C3、IL-Ⅱ、E-RFC、T-LTT、抗心肌抗体的检查;然后将CHF组患者随机分为两组,治疗组在应用转换酶抑制剂、利尿剂和强心苷等常规治疗的基础上加用黄芪注射液60mL+10%葡萄糖注射液500mL静脉滴注,每日1次,连用2周,对照组仅给予常规治疗;2周后重复上述检查,进行体检组与CHF和治疗组与对照组的对比分析。结果体检组与CHF组比较,IL-Ⅱ、E-RFC、T-LTT、C3和抗心肌抗体CHF组明显高于体检组(P<0.05);治疗2周后,两组比较心衰治疗的总有效率无明显差异(P>0.05),但显效率治疗组明显优于对照组(P<0.05);治疗组IL-Ⅱ、E-RFC、T-LTT、C3和抗心肌抗体的改变明显优于对照组(P<0.01)。结论黄芪注射液对心衰的疗效很大程度上是通过对细胞免疫作用实现的,其辅助治疗可获满意的疗效。
- 心力衰竭 /
- 充血性 /
- 免疫 /
- 黄芪注射液
Abstract: Objective To explore the effect of Astragalus membranaceus injection on congestive heart failure and immune regulation. Methods The serum levers of IgA IgG IgM C3 IL-Ⅱ E-RFC T-LTT and antibody of cardiac muscle were measured in normal control group and CHF group. Then the CHF patients were divided randomly into two groups. Treatment group was infused intravenously daily with Astragalus membranaceus injection added into 5% glucose 250mL for two weeks, which was based on conventional therapy such as digitalis, diuretics and vasodilators. Conventional therapy group was only treated with conventional thearpy. Previous measurements were done again after two weeks. Comparative analysis was made between normal control group and CHF group, and also was made between conventional therapy group and treatment group. Results The level of IL-Ⅱ E-RFC T-LTT antibody of cardiac muscle in the CHF paients were significantly higher then that of normal control group (P<0.01). After two weeks, there was no significant difference in the total effective rate of CHF between two groups (P>0.05), but the obvious effective rate of treatment group was markedly higher than that of conventional therapy group(P >0.05). The decrease of IL-Ⅱ E-RFC T-LTT C3 and antibody of cardiac muscle in treatment group is more obvious than that in conventional therapy group (P<0.01). Conclusion The effect of Astragalus membranaceus injection on cogestive heart failure involves mainly the cell immune and Astragalus membranaceus may have a satisfied cure effect on it.
- Astragalus membranaceus /
- heart failure /
- congestive /
- immunity

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黄芪注射液辅助治疗充血性心力衰竭的疗效及对免疫调节影响的观察

湖北省荆州市第三人民医院, 湖北荆州 434001

收稿日期: 2004-04-08

关键词:

心力衰竭 /

充血性 /

免疫 /

黄芪注射液

摘要: 目的探讨黄芪注射液对充血性心力衰竭(CHF)患者的疗效及对免疫调节的影响。方法对正常体检查者(体检组)和CHF组进行IgA、IgG、IgM、C3、IL-Ⅱ、E-RFC、T-LTT、抗心肌抗体的检查;然后将CHF组患者随机分为两组,治疗组在应用转换酶抑制剂、利尿剂和强心苷等常规治疗的基础上加用黄芪注射液60mL+10%葡萄糖注射液500mL静脉滴注,每日1次,连用2周,对照组仅给予常规治疗;2周后重复上述检查,进行体检组与CHF和治疗组与对照组的对比分析。结果体检组与CHF组比较,IL-Ⅱ、E-RFC、T-LTT、C3和抗心肌抗体CHF组明显高于体检组(P<0.05);治疗2周后,两组比较心衰治疗的总有效率无明显差异(P>0.05),但显效率治疗组明显优于对照组(P<0.05);治疗组IL-Ⅱ、E-RFC、T-LTT、C3和抗心肌抗体的改变明显优于对照组(P<0.01)。结论黄芪注射液对心衰的疗效很大程度上是通过对细胞免疫作用实现的,其辅助治疗可获满意的疗效。

English Abstract

Effect of astragalus membranaceus injection on congestive heart failure and im- mune regulation

The Third People Hospital of Jingzhou City, Jingzhou 434001, China

Received Date: 2004-04-08

Keywords:

Abstract: Objective To explore the effect of Astragalus membranaceus injection on congestive heart failure and immune regulation. Methods The serum levers of IgA IgG IgM C3 IL-Ⅱ E-RFC T-LTT and antibody of cardiac muscle were measured in normal control group and CHF group. Then the CHF patients were divided randomly into two groups. Treatment group was infused intravenously daily with Astragalus membranaceus injection added into 5% glucose 250mL for two weeks, which was based on conventional therapy such as digitalis, diuretics and vasodilators. Conventional therapy group was only treated with conventional thearpy. Previous measurements were done again after two weeks. Comparative analysis was made between normal control group and CHF group, and also was made between conventional therapy group and treatment group. Results The level of IL-Ⅱ E-RFC T-LTT antibody of cardiac muscle in the CHF paients were significantly higher then that of normal control group (P<0.01). After two weeks, there was no significant difference in the total effective rate of CHF between two groups (P>0.05), but the obvious effective rate of treatment group was markedly higher than that of conventional therapy group(P >0.05). The decrease of IL-Ⅱ E-RFC T-LTT C3 and antibody of cardiac muscle in treatment group is more obvious than that in conventional therapy group (P<0.01). Conclusion The effect of Astragalus membranaceus injection on cogestive heart failure involves mainly the cell immune and Astragalus membranaceus may have a satisfied cure effect on it.

柯晓, 周宗梅, 文明, 文彩云. 黄芪注射液辅助治疗充血性心力衰竭的疗效及对免疫调节影响的观察[J]. 药学实践与服务, 2004, (5): 268-270.

引用本文:

柯晓, 周宗梅, 文明, 文彩云. 黄芪注射液辅助治疗充血性心力衰竭的疗效及对免疫调节影响的观察[J]. 药学实践与服务, 2004, (5): 268-270.

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黄芪注射液辅助治疗充血性心力衰竭的疗效及对免疫调节影响的观察

Effect of astragalus membranaceus injection on congestive heart failure and im- mune regulation

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黄芪注射液辅助治疗充血性心力衰竭的疗效及对免疫调节影响的观察

湖北省荆州市第三人民医院, 湖北 荆州 434001

English Abstract

Effect of astragalus membranaceus injection on congestive heart failure and im- mune regulation

The Third People Hospital of Jingzhou City, Jingzhou 434001, China

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湖北省荆州市第三人民医院, 湖北荆州 434001