泼尼松龙新型靶向脂质体制剂对嘌呤霉素氨基核苷肾病的疗效

刘丽华; 欧周罗; 朱春芳; 王磊

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泼尼松龙新型靶向脂质体制剂对嘌呤霉素氨基核苷肾病的疗效

刘丽华, 欧周罗, 朱春芳, 王磊

文章导航 > 药学实践与服务 > 2004 > (3): 138-140

刘丽华, 欧周罗, 朱春芳, 王磊. 泼尼松龙新型靶向脂质体制剂对嘌呤霉素氨基核苷肾病的疗效[J]. 药学实践与服务, 2004, (3): 138-140.

引用本文:

刘丽华, 欧周罗, 朱春芳, 王磊. 泼尼松龙新型靶向脂质体制剂对嘌呤霉素氨基核苷肾病的疗效[J]. 药学实践与服务, 2004, (3): 138-140.

LIU Li-hua, OU Zhou-luo, Zhu, Chun-fang. Therapeutic effect of a new liposome-prednisolone on the puromycin aminonucleoside nephropathy in rats[J]. Journal of Pharmaceutical Practice and Service, 2004, (3): 138-140.

Citation:

LIU Li-hua, OU Zhou-luo, Zhu, Chun-fang. Therapeutic effect of a new liposome-prednisolone on the puromycin aminonucleoside nephropathy in rats[J]. Journal of Pharmaceutical Practice and Service, 2004, (3): 138-140.

泼尼松龙新型靶向脂质体制剂对嘌呤霉素氨基核苷肾病的疗效

1.
复旦大学上海医学院生物化学与分子生物学系, 上海 200032;绍兴文理学院医学院生物化学教研室, 浙江绍兴 312000
2.
复旦大学上海医学院生物化学与分子生物学系, 上海 200032

Therapeutic effect of a new liposome-prednisolone on the puromycin aminonucleoside nephropathy in rats

1.
Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China;Department of Biochemistry, Medical College, Shaoxing College of Arts and Sciences, Shaoxing 312000, China
2.
Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China

摘要: 目的观察肾小球向性泼尼松龙新型靶向脂质体制剂对嘌呤霉素氨基核苷性肾病的治疗作用。方法选用雄性Wistar大鼠,按照嘌呤霉素氨基核苷(puromycin amino neucleoside,PAN) 4.0mg/100g体重的剂量建立大鼠PAN模型,以泼尼松龙(prednisolone,PRED) 2mg/100g体重及泼尼松龙新型靶向脂质体制剂(liposome-prednisolone,Lipo-PRED) 1.5mg/100g体重的剂量进行治疗,观察尿蛋白的排出量、肾组织白细胞浸润等。结果泼尼松龙新型靶向脂质体制剂治疗组尿蛋白排泄量显著性降低,肾组织中白细胞浸润减少,其作用优于泼尼松龙治疗组结论泼尼松龙新型靶向脂质体制剂可显著性抑制PAN模型的尿蛋白排泄量和急性期肾间质白细胞浸润。
- 泼尼松龙 /
- 泼尼松龙脂质体制剂 /
- 嘌呤霉素氨基核苷 /
- 蛋白尿
Abstract: Objective To observe the effect of a novel liposome-prednisolone on puromycin aminonucleoside (PAN) nephropathy model in rats. Methods 160～180g BW male Wistar rats were used in this experiment. The rats were given a single injection of PAN at the dose of 4mg/100g BW through right jugular vein to establish the nephrotic syndrome (NS) model. The free prednisolone (PRED) treated group were given (i.p.) the free prednisolone at the dose of 2.0mg/100g BW and the liposome prednisolone (Lipo-PRED) treated group were given (i.v.) the liposome prednisolone at the dose of 1.5mg/100g BW. Urinary protein excretion examined with the biuret method and the monocyte/macrophage, CD₄⁺ T cells and CD₈⁺T cells were analyzed by immunohistochemistry. Results The proteinuria of the Lipo-PRED treated group reduced; the infiltration of monocyte/macrophages, CD₄⁺T cells and CD₈⁺T cells in the glomeruli and interstitium also remarkably weakened. Conclusion The liposome prednisolone can remarkably reduce the proteinuria excretion and leukocyte infiltration both in the glomeruli and tubulointerstitium in the PAN model.
- prednisolone /
- liposome-prednisolone (lipo-PRED) /
- puromecin aminoneucleoside (PAN) /
- proteinuria

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泼尼松龙新型靶向脂质体制剂对嘌呤霉素氨基核苷肾病的疗效

1. 复旦大学上海医学院生物化学与分子生物学系, 上海 200032;绍兴文理学院医学院生物化学教研室, 浙江绍兴 312000

2. 复旦大学上海医学院生物化学与分子生物学系, 上海 200032

收稿日期: 2003-12-29

关键词:

摘要: 目的观察肾小球向性泼尼松龙新型靶向脂质体制剂对嘌呤霉素氨基核苷性肾病的治疗作用。方法选用雄性Wistar大鼠,按照嘌呤霉素氨基核苷(puromycin amino neucleoside,PAN) 4.0mg/100g体重的剂量建立大鼠PAN模型,以泼尼松龙(prednisolone,PRED) 2mg/100g体重及泼尼松龙新型靶向脂质体制剂(liposome-prednisolone,Lipo-PRED) 1.5mg/100g体重的剂量进行治疗,观察尿蛋白的排出量、肾组织白细胞浸润等。结果泼尼松龙新型靶向脂质体制剂治疗组尿蛋白排泄量显著性降低,肾组织中白细胞浸润减少,其作用优于泼尼松龙治疗组结论泼尼松龙新型靶向脂质体制剂可显著性抑制PAN模型的尿蛋白排泄量和急性期肾间质白细胞浸润。

English Abstract

Therapeutic effect of a new liposome-prednisolone on the puromycin aminonucleoside nephropathy in rats

1. Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China;Department of Biochemistry, Medical College, Shaoxing College of Arts and Sciences, Shaoxing 312000, China

2. Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China

Received Date: 2003-12-29

Keywords:

Abstract: Objective To observe the effect of a novel liposome-prednisolone on puromycin aminonucleoside (PAN) nephropathy model in rats. Methods 160～180g BW male Wistar rats were used in this experiment. The rats were given a single injection of PAN at the dose of 4mg/100g BW through right jugular vein to establish the nephrotic syndrome (NS) model. The free prednisolone (PRED) treated group were given (i.p.) the free prednisolone at the dose of 2.0mg/100g BW and the liposome prednisolone (Lipo-PRED) treated group were given (i.v.) the liposome prednisolone at the dose of 1.5mg/100g BW. Urinary protein excretion examined with the biuret method and the monocyte/macrophage, CD₄⁺ T cells and CD₈⁺T cells were analyzed by immunohistochemistry. Results The proteinuria of the Lipo-PRED treated group reduced; the infiltration of monocyte/macrophages, CD₄⁺T cells and CD₈⁺T cells in the glomeruli and interstitium also remarkably weakened. Conclusion The liposome prednisolone can remarkably reduce the proteinuria excretion and leukocyte infiltration both in the glomeruli and tubulointerstitium in the PAN model.

刘丽华, 欧周罗, 朱春芳, 王磊. 泼尼松龙新型靶向脂质体制剂对嘌呤霉素氨基核苷肾病的疗效[J]. 药学实践与服务, 2004, (3): 138-140.

引用本文:

刘丽华, 欧周罗, 朱春芳, 王磊. 泼尼松龙新型靶向脂质体制剂对嘌呤霉素氨基核苷肾病的疗效[J]. 药学实践与服务, 2004, (3): 138-140.

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泼尼松龙新型靶向脂质体制剂对嘌呤霉素氨基核苷肾病的疗效

Therapeutic effect of a new liposome-prednisolone on the puromycin aminonucleoside nephropathy in rats

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泼尼松龙新型靶向脂质体制剂对嘌呤霉素氨基核苷肾病的疗效

1. 复旦大学上海医学院生物化学与分子生物学系, 上海 200032;绍兴文理学院医学院生物化学教研室, 浙江 绍兴 312000 2. 复旦大学上海医学院生物化学与分子生物学系, 上海 200032

English Abstract

Therapeutic effect of a new liposome-prednisolone on the puromycin aminonucleoside nephropathy in rats

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1. 复旦大学上海医学院生物化学与分子生物学系, 上海 200032;绍兴文理学院医学院生物化学教研室, 浙江绍兴 312000

2. 复旦大学上海医学院生物化学与分子生物学系, 上海 200032