他莫昔酚对耐药细胞系K562/DOX多药耐药逆转作用的研究
Study on the reversing effect of tamoxifen on multidrug resistant cell line K562/DOX
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摘要: 目的 寻找有效的多药耐药逆转剂。方法 以他莫昔酚作为耐药逆转剂,用[溴化-3(4,5-二甲基-2-噻唑基)-2,5-二苯基四唑氮]MTT法体外药物敏感试验,观察他莫昔酚对多药耐药白血病细胞株K562/DOX的药物敏感性的影响。结果 他莫昔酚可增强阿霉素(DOX)对K562/DOX的细胞毒作用,对K562细胞无影响。结论 他莫昔酚是一种有效的多药耐药逆转剂。Abstract: OBJECTIVE To develop effect of tamoxifen on resistance modulators. METHODS The effects of tamoxifen on drug sensitivity in multidrug resistant human leukemic cell line K562/DOX were studied by MTT corlori- metric assay. RESULTS:Tamoxifen enhanced the cytotoxicity of doxorubicin (DOX) to K562/DOX and had no effect on efflux of DOX in K562 cells. CONCLUSION Tamoxifen is an effective reversal agent of multidrug resistance.
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Key words:
- tamoxifen /
- trug tolerance /
- effective reversal agent
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