氟哌酸胶囊溶出度测定方法的试验
Study on the method of dissolution test of norfloxacin Capsule
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摘要: 目的 探讨紫外分光光度法测定氟哌酸胶囊含量的条件、方法和氟哌酸胶囊溶出度的测定。方法 用紫外分光光度法测定氟哌酸胶囊含量及转篮法测定其溶出度。结果 在273nm波长处有最大吸收(5μg/ml,0.4%氢氧化钠溶液),其吸收系数平均值(E1cm1%)为1095,线性关系良好(r=0.9998).20min溶出率(%)均在80%。结论 氟哌酸胶囊含量测定可采用紫外分光光度法,简便易行,快速准确。同时可用于氟哌酸胶囊溶出度测定。Abstract: OBJECTIVE To study the condition and method using UV-spectrophotomery for determining the concentration and dissolution of Norfloxacin capsule.METHODS The concentration of Norfloxacin capsule was detected by UV-spectrophotometry and the dissolution was detected by rotation basket method.RESULTS The iggest absorbtion was at 273nm wavelength(5μg/ml,0.4% NaOH solution).The average absorption coefficient(E1cm1%)is 1095,And the linear relationship was good(r=0 9998)In 20minutes,the dissolution rates were 80%.CONCLUSION The concentration of Norfloxacin can be detected by UV-spectrophotometry,it′s convient and rapid.It can also be wsed to detect the dvssolution of Norfloxacin capsule.
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Key words:
- norfloxacin capsule /
- UV-Spectrophotometry /
- dissolution
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