乳酸环丙沙星滴眼液的研制
The preparation of ciprofloxacin eye drops
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摘要: 本文根据乳酸环丙沙星的理化特性,制备了两种不同 pH值的乳酸环丙沙星滴眼液;并通过初均速加速实验法和随机交叉试验考察两种制剂的稳定性和刺激性.结果表明,两种满眼液对眼均无刺激,室温预测有效期分别为2.3年和5.8年.Abstract: To satisfy the clinical needs of ophthalmologist and expand the preparations of ciprofloxacin,two diffent pH eye ha were prepared according to the physi-chemical character of ciprofloxacin. By the acelerated test and random-crossed test, the stabilities and stimulation of the two preparations were examined. The results showed that the two preparations had no stimulation to eyes of rabits and the anticipate efective time were 2.3 years and 5.8 years separately. One of the preparations could be selected and used for clinical experiment.
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Key words:
- ciprofloxacin /
- eye drops /
- stability /
- stimulation
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