氨基糖甙类的抗菌后效应及新给药方案
The postantibiotic effect and new administrative regimen of aminoglycosides
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摘要: 本文引述了氨基糖甙类的抗菌后效应,为每日给药一次方案提供了理论依据。新方案通过减少细菌暴露于药物的时间,降低了肾毒性、耳毒性,并推迟了耐药性出现。其疗效则与传统方案相等。研究资料显示,氨基糖甙类采用一日给药一次是可行的,对患者尤其是肾功不全患者是有益的。
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关键词:
- 氨基糖甙类/给药方案 /
- 抗菌后效应 /
- 耐药性 /
- 耳毒性 /
- 肾毒性
Abstract: The postantibiotic effect(PAE)is reviewed in this article, which provides theory basis for once-daily administration of aminoglycosides. The new regimen has equally effective as traditional regimens. Also,it may delays the occurance for postexposure resistance by reducing contact time between the organism and the drug,and reduces nephrotoxicity and ototoxicity that caused by the accumulation of drugs, The data on studies has shown that once-daily administration of aminoglycosides is advisable. Patients, espacially the patient with renal dysfunction,may benifit from once-daily administration of aminoglycosides.-
Key words:
- aminoglycosides /
- postantibiotic effect /
- postexposure resistance /
- nephrotoxicity /
- ototoxicity
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