扑热息痛直肠胶囊剂的溶出度和生物利用度研究

盛杰; 郑志安; 周嘉秀; 姜宏颖; 晏艳; 葛启

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扑热息痛直肠胶囊剂的溶出度和生物利用度研究

盛杰, 郑志安, 周嘉秀, 姜宏颖, 晏艳, 葛启

文章导航 > 药学实践与服务 > 1995 > (3): 161-164

盛杰, 郑志安, 周嘉秀, 姜宏颖, 晏艳, 葛启. 扑热息痛直肠胶囊剂的溶出度和生物利用度研究[J]. 药学实践与服务, 1995, (3): 161-164.

引用本文:

盛杰, 郑志安, 周嘉秀, 姜宏颖, 晏艳, 葛启. 扑热息痛直肠胶囊剂的溶出度和生物利用度研究[J]. 药学实践与服务, 1995, (3): 161-164.

Sheng Jie, Zheng Zhian, Zhou Jiaxiu, Jiang Hongying, Yan Yan, Ge Qi. Studies on the dissolution and bioavailability of the rectal capsule of acetaminophene[J]. Journal of Pharmaceutical Practice and Service, 1995, (3): 161-164.

Citation:

Sheng Jie, Zheng Zhian, Zhou Jiaxiu, Jiang Hongying, Yan Yan, Ge Qi. Studies on the dissolution and bioavailability of the rectal capsule of acetaminophene[J]. Journal of Pharmaceutical Practice and Service, 1995, (3): 161-164.

扑热息痛直肠胶囊剂的溶出度和生物利用度研究

1.
空军兰州医院药剂科兰州 730070
2.
空军兰州医院药剂科兰州 730070;兰州医药站 730050
3.
空军兰州医院药剂科兰州 730070;新疆金地市87148部队卫生队 832200

Studies on the dissolution and bioavailability of the rectal capsule of acetaminophene

1.
Department of Pharmacy, Lanzhou Airforce Hospital, 730070
2.
Department of Pharmacy, Lanzhou Airforce Hospital, 730070
3.
Department of Pharmacy, Lanzhou Airforce Hospital, 730070

摘要: 作者制备的扑热息痛直肠胶囊剂,可根据小儿体重分装成不同规格,便于临床实现个体化给药。本品与市售栓剂在家兔体内的达峰时分别为1.87,1.67h;峰浓度及AUC分别为54.86,46.09(mg/L)和198.94,188.94(mg·h/L).直肠胶囊剂用自行设计的"转筒膜法"测定,体外累积溶出百分率与体内吸收百分率间有显着相关性(r=0.9929,n=7).
- 扑热息痛 /
- 直肠胶囊剂 /
- 溶出度 /
- 转筒膜法 /
- 生物利用度
Abstract: The rectal capsule of acetaminophene was prepared, it can be formed several sizes by children's weight so as to administrate in personal. Tmax, Cmax and AUC of the capsule and the suppository commercial were 1.87, 1.67h; 54.86, 46.69(μg/ml); 198.94, 188.94 (μg·h/ml) in rabbits respectively, the results showed that the suppository of acetaminophene can be substitued by the rectal capsule, it was a new dosage form in rectal administration, it's dissolution in vitro was determined by the method of rotating-cylinder with millipore memberane(RCMM) established by ourself. There are a significant correlation between the cumulative dissolution rates in vitro and the absorption rates in vivo, and the both meets zero-order kinetics, the results showed that RCMM could simulated the dissolution of rectal capsule in rectal, it provided a new method of determing dissolution of soluble suppositories, RCMM can simulated the conditions of poor liquid, pH≈7, temperature higher than body temperature but cann't simulated the larger absorption area and the pressure of rectal acting on preparations in rectal, it has several advantages such as simple operating, fixed diffusion area, regulating millipore memberane and non-ignoring the differances of preparations.
- acetaminophene /
- rectal capsule /
- dissolution /
- bioavailability /

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扑热息痛直肠胶囊剂的溶出度和生物利用度研究

1. 空军兰州医院药剂科兰州 730070

2. 空军兰州医院药剂科兰州 730070;兰州医药站 730050

3. 空军兰州医院药剂科兰州 730070;新疆金地市87148部队卫生队 832200

关键词:

溶出度 /

摘要: 作者制备的扑热息痛直肠胶囊剂,可根据小儿体重分装成不同规格,便于临床实现个体化给药。本品与市售栓剂在家兔体内的达峰时分别为1.87,1.67h;峰浓度及AUC分别为54.86,46.09(mg/L)和198.94,188.94(mg·h/L).直肠胶囊剂用自行设计的"转筒膜法"测定,体外累积溶出百分率与体内吸收百分率间有显着相关性(r=0.9929,n=7).

English Abstract

Studies on the dissolution and bioavailability of the rectal capsule of acetaminophene

1. Department of Pharmacy, Lanzhou Airforce Hospital, 730070

2. Department of Pharmacy, Lanzhou Airforce Hospital, 730070

3. Department of Pharmacy, Lanzhou Airforce Hospital, 730070

Keywords:

Abstract: The rectal capsule of acetaminophene was prepared, it can be formed several sizes by children's weight so as to administrate in personal. Tmax, Cmax and AUC of the capsule and the suppository commercial were 1.87, 1.67h; 54.86, 46.69(μg/ml); 198.94, 188.94 (μg·h/ml) in rabbits respectively, the results showed that the suppository of acetaminophene can be substitued by the rectal capsule, it was a new dosage form in rectal administration, it's dissolution in vitro was determined by the method of rotating-cylinder with millipore memberane(RCMM) established by ourself. There are a significant correlation between the cumulative dissolution rates in vitro and the absorption rates in vivo, and the both meets zero-order kinetics, the results showed that RCMM could simulated the dissolution of rectal capsule in rectal, it provided a new method of determing dissolution of soluble suppositories, RCMM can simulated the conditions of poor liquid, pH≈7, temperature higher than body temperature but cann't simulated the larger absorption area and the pressure of rectal acting on preparations in rectal, it has several advantages such as simple operating, fixed diffusion area, regulating millipore memberane and non-ignoring the differances of preparations.

盛杰, 郑志安, 周嘉秀, 姜宏颖, 晏艳, 葛启. 扑热息痛直肠胶囊剂的溶出度和生物利用度研究[J]. 药学实践与服务, 1995, (3): 161-164.

引用本文:

盛杰, 郑志安, 周嘉秀, 姜宏颖, 晏艳, 葛启. 扑热息痛直肠胶囊剂的溶出度和生物利用度研究[J]. 药学实践与服务, 1995, (3): 161-164.

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扑热息痛直肠胶囊剂的溶出度和生物利用度研究

Studies on the dissolution and bioavailability of the rectal capsule of acetaminophene

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扑热息痛直肠胶囊剂的溶出度和生物利用度研究

1. 空军兰州医院药剂科 兰州 730070 2. 空军兰州医院药剂科 兰州 730070;兰州医药站 730050 3. 空军兰州医院药剂科 兰州 730070;新疆金地市87148部队卫生队 832200

English Abstract

Studies on the dissolution and bioavailability of the rectal capsule of acetaminophene

1. Department of Pharmacy, Lanzhou Airforce Hospital, 730070 2. Department of Pharmacy, Lanzhou Airforce Hospital, 730070 3. Department of Pharmacy, Lanzhou Airforce Hospital, 730070

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目录

1. 空军兰州医院药剂科兰州 730070

2. 空军兰州医院药剂科兰州 730070;兰州医药站 730050

3. 空军兰州医院药剂科兰州 730070;新疆金地市87148部队卫生队 832200

1. Department of Pharmacy, Lanzhou Airforce Hospital, 730070

2. Department of Pharmacy, Lanzhou Airforce Hospital, 730070

3. Department of Pharmacy, Lanzhou Airforce Hospital, 730070