胆碱能抗炎通路α7烟碱型乙酰胆碱受体的最新研究进展

张慧敏; 向科发; 史小飞; 秦臻; 刘霞; 张慧敏; 向科发; 史小飞; 秦臻; 刘霞

doi:10.12206/j.issn.2097-2024.202204037

[1]

王大伟, 周荣斌, 姚咏明. 胆碱能抗炎通路在炎症反应中的作用[J]. 生理科学进展, 2010, 41(3):217-220.

[2]

BOUZAT C, LASALA M, NIELSEN B E, et al. Molecular function of α7 nicotinic receptors as drug targets[J]. J Physiol,2018,596(10):1847-1861. doi: 10.1113/JP275101

[3]

BERTRAND D, LEE C H, FLOOD D, et al. Therapeutic potential of α7 nicotinic acetylcholine receptors[J]. Pharmacol Rev, 2015, 67(4): 1025-1073.

[4]

MACKLIN K D, MAUS A D, PEREIRA E F, et al. Human vascular endothelial cells express functional nicotinic acetylcholine receptors[J]. J Pharmacol Exp Ther,1998,287(1):435-439.

[5]

CHEN L Y, LIU Z G, LI Y H, et al. Expression of neuronal acetylcholine receptor alpha 7 (nAChRalpha7) in peripheral blood CD(4)(+) T lymphocytes from asthmatic children[J]. Chin J Tuberc Respir Dis,2008,31(11):803-805.

[6]

KALKMAN H O, FEUERBACH D. Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders[J]. Cell Mol Life Sci,2016,73(13):2511-2530. doi: 10.1007/s00018-016-2175-4

[7]

CORRADI J, BOUZAT C. Understanding the bases of function and modulation of α7 nicotinic receptors: implications for drug discovery[J]. Mol Pharmacol,2016,90(3):288-299. doi: 10.1124/mol.116.104240

[8]

KABBANI N, NICHOLS R A. Beyond the channel: metabotropic signaling by nicotinic receptors[J]. Trends Pharmacol Sci,2018,39(4):354-366. doi: 10.1016/j.tips.2018.01.002

[9]

BOROVIKOVA L V, IVANOVA S, ZHANG M, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin[J]. Nature,2000,405(6785):458-462. doi: 10.1038/35013070

[10]

余江, 张恒, 张润峰. 胆碱能抗炎通路及其调控心脏炎症反应的作用[J]. 中国心血管病研究, 2021, 19(9):843-848. doi: 10.3969/j.issn.1672-5301.2021.09.017

[11]

马莉, 冷玉芳, 张梦婕, 等. 胆碱能抗炎通路对器官的保护研究进展[J]. 兰州大学学报(医学版), 2020, 46(1):10-15. doi: 10.13885/j.issn.1000-2812.2020.01.003

[12]

QIN Z, XIANG K F, SU D F, et al. Activation of the cholinergic anti-inflammatory pathway as a novel therapeutic strategy for COVID-19[J]. Front Immunol,2020,11:595342.

[13]

WANG H, YU M, OCHANI M, et al. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation[J]. Nature,2003,421(6921):384-388. doi: 10.1038/nature01339

[14]

陈卓, 何骁, 姚孟维, 等. 胆碱能炎症反射与炎症消退研究进展[J]. 中华烧伤杂志, 2021, 37(9):885-889. doi: 10.3760/cma.j.cn501120-20200609-00299

[15]

李祺, 刘霞. 胆碱能抗炎通路的信号机制研究[J]. 药学实践杂志, 2010, 28(5):325-327,338.

[16]

HOOVER D B. Cholinergic modulation of the immune system presents new approaches for treating inflammation[J]. Pharmacol Ther,2017,179:1-16. doi: 10.1016/j.pharmthera.2017.05.002

[17]

王娜, 苏跃. 全身炎症反应综合征治疗新策略: 胆碱能抗炎通路[J]. 医学与哲学, 2010, 31(22):42-43,77.

[18]

资双凤, 李景辉, 刘蕾, 等. 胆碱能抗炎通路及其在脓毒症治疗中的作用[J]. 中南大学学报(医学版), 2020, 45(1):68-73.

[19]

BROGNARA F, CASTANIA J A, DIAS D P M, et al. Baroreflex stimulation attenuates central but not peripheral inflammation in conscious endotoxemic rats[J]. Brain Res,2018,1682:54-60. doi: 10.1016/j.brainres.2018.01.003

[20]

SAPRONOV N S, NEZHINSKAYA G I, VLADYKIN A L. Effects of cholinergic agonists and antagonists under conditions of spleen denervation in rats with endotoxic shock[J]. Bull Exp Biol Med,2010,149(5):598-600. doi: 10.1007/s10517-010-1002-4

[21]

RIVERA C A, WHEELER M D, ENOMOTO N, et al. A choline-rich diet improves survival in a rat model of endotoxin shock[J]. Am J Physiol,1998,275(4):G862-G867.

[22]

BENCHERIF M, LIPPIELLO P M, LUCAS R, et al. Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases[J]. Cell Mol Life Sci,2011,68(6):931-949. doi: 10.1007/s00018-010-0525-1

[23]

PAVLOV V A, PARRISH W R, ROSAS-BALLINA M, et al. Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway[J]. Brain Behav Immun,2009,23(1):41-45. doi: 10.1016/j.bbi.2008.06.011

[24]

郑紫磊, 郭睿, 郜思齐, 等. 迷走神经刺激活化胆碱能抗炎通路对创伤/失血性休克的干预作用[J]. 河北医药, 2021, 43(16):2531-2535. doi: 10.3969/j.issn.1002-7386.2021.16.031

[25]

KOHOUTOVA M, HORAK J, JARKOVSKA D, et al. Vagus nerve stimulation attenuates multiple organ dysfunction in resuscitated porcine progressive Sepsis[J]. Crit Care Med,2019,47(6):e461-e469. doi: 10.1097/CCM.0000000000003714

[26]

李建国, 胡正芳, 杜朝晖, 等. 胆碱能抗炎通路对失血性休克大鼠保护作用的研究[J]. 中国危重病急救医学, 2005(1):24-27.

[27]

宫丽荣, 董树安, 阚永星, 等. α7烟碱型乙酰胆碱受体在电针减轻肢体缺血再灌注兔肺损伤中的作用[J]. 中国中西医结合外科杂志, 2019, 25(4):443-447. doi: 10.3969/j.issn.1007-6948.2019.04.004

[28]

田甜, 何君艺, 樊素雄, 等. α7烟碱型乙酰胆碱受体对缺血再灌注损伤影响的研究现状[J]. 中国临床药理学杂志, 2020, 36(18):2914-2917.

[29]

MA Z, ZHANG Z L, BAI F H, et al. Electroacupuncture pretreatment alleviates cerebral ischemic injury through α7 nicotinic acetylcholine receptor-mediated phenotypic conversion of microglia[J]. Front Cell Neurosci,2019,13:537.

[30]

XIE J L, LI X, ZHANG L M, et al. Genistein-3'-sodium sulfonate ameliorates cerebral ischemia injuries by blocking neuroinflammation through the α7nAChR-JAK2/STAT3 signaling pathway in rats[J]. Phytomedicine,2021,93:153745. doi: 10.1016/j.phymed.2021.153745

[31]

MUNYAKA P, RABBI M F, PAVLOV V A, et al. Central muscarinic cholinergic activation alters interaction between splenic dendritic cell and CD4+CD25- T cells in experimental colitis[J]. PLoS One,2014,9(10):e109272. doi: 10.1371/journal.pone.0109272

[32]

SHAO B Z, WANG S L, FANG J, et al. Alpha7 nicotinic acetylcholine receptor alleviates inflammatory bowel disease through induction of AMPK-mTOR-p70S6K-mediated autophagy[J]. Inflammation,2019,42(5):1666-1679. doi: 10.1007/s10753-019-01027-9

[33]

WAZEA S A, WADIE W, BAHGAT A K, et al. Galantamine anti-colitic effect: role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways[J]. Sci Rep,2018,8(1):5110. doi: 10.1038/s41598-018-23359-6

[34]

NUNES N S, CHANDRAN P, SUNDBY M, et al. Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway[J]. EBioMedicine,2019,45:495-510. doi: 10.1016/j.ebiom.2019.06.033

[35]

HARMYCH S J, KUMAR J, BOUNI M E, et al. Nicotine inhibits MAPK signaling and spheroid invasion in ovarian cancer cells[J]. Exp Cell Res,2020,394(1):112167. doi: 10.1016/j.yexcr.2020.112167

[36]

OFFERHAUS G J, TERSMETTE A C, HUIBREGTSE K, et al. Mortality caused by stomach cancer after remote partial gastrectomy for benign conditions: 40 years of follow up of an Amsterdam cohort of 2633 postgastrectomy patients[J]. Gut,1988,29(11):1588-1590. doi: 10.1136/gut.29.11.1588

[37]

AHSBERG K, OLSSON H, VON HOLSTEIN C S. Increased mortality in prostate carcinoma and smoking-related disease after parietal cell vagotomy: a long-term follow-up study[J]. Scand J Gastroenterol,2009,44(8):947-951. doi: 10.1080/00365520903039945

[38]

OGAWA T, MAKINO T, MIZUMOTO K, et al. Promoting effect of truncal vagotomy on pancreatic carcinogenesis initiated with N-nitrosobis(2-oxopropyl)amine in Syrian golden hamsters[J]. Carcinogenesis,1991,12(7):1227-1230. doi: 10.1093/carcin/12.7.1227

[39]

MORGENSTERN L. Vagotomy, gastroenterostomy and experimental gastic cancer[J]. Arch Surg,1968,96(6):920-923. doi: 10.1001/archsurg.1968.01330240066014

[40]

KOWALEWSKI K. Relationship between vagotomy, peptic ulcer and gastric adenocarcinoma in rats fed 2, 7-diacetylaminogluorene[J]. Can J Surg,1973,16(3):210-217.

[41]

ERIN N, DUYMUŞ O, OZTÜRK S, et al. Activation of vagus nerve by semapimod alters substance P levels and decreases breast cancer metastasis[J]. Regul Pept,2012,179(1-3):101-108. doi: 10.1016/j.regpep.2012.08.001

[42]

REIJMEN E, VANNUCCI L, DE COUCK M, et al. Therapeutic potential of the vagus nerve in cancer[J]. Immunol Lett,2018,202:38-43. doi: 10.1016/j.imlet.2018.07.006

[43]

WINEK K, SOREQ H, MEISEL A. Regulators of cholinergic signaling in disorders of the central nervous system[J]. J Neurochem,2021,158(6):1425-1438. doi: 10.1111/jnc.15332

[44]

SCHUHMANN M K, PAPP L, STOLL G, et al. Mesencephalic electrical stimulation reduces neuroinflammation after photothrombotic stroke in rats by targeting the cholinergic anti-inflammatory pathway[J]. Int J Mol Sci,2021,22(3):1254. doi: 10.3390/ijms22031254

[45]

LIU D, LI T, LUO H, et al. The effect of the cholinergic anti-inflammatory pathway on collagen-induced arthritis involves the modulation of dendritic cell differentiation[J]. Arthritis Res Ther,2018,20(1):263. doi: 10.1186/s13075-018-1759-9

[46]

LI S, ZHOU B, LIU B, et al. Activation of the cholinergic anti-inflammatory system by nicotine attenuates arthritis via suppression of macrophage migration[J]. Mol Med Rep,2016,14(6):5057-5064. doi: 10.3892/mmr.2016.5904

[47]

WU S Y, LUO H, XIAO X Z, et al. Attenuation of collagen induced arthritis via suppression on Th17 response by activating cholinergic anti-inflammatory pathway with nicotine[J]. Eur J Pharmacol,2014,735:97-104. doi: 10.1016/j.ejphar.2014.04.019

[48]

WU S Y, ZHAO H J, LUO H, et al. GTS-21, an α7-nicotinic acetylcholine receptor agonist, modulates Th1 differentiation in CD4⁺ T cells from patients with rheumatoid arthritis[J]. Exp Ther Med,2014,8(2):557-562. doi: 10.3892/etm.2014.1754

[49]

VAN MAANEN M A, LEBRE M C, VAN DER POLL T, et al. Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice[J]. Arthritis Rheum,2009,60(1):114-122. doi: 10.1002/art.24177

[50]

YI L, KE J Y, LIU J Y, et al. Sinomenine increases adenosine A 2A receptor and inhibits NF-κB to inhibit arthritis in adjuvant-induced-arthritis rats and fibroblast-like synoviocytes through α7nAChR[J]. J Leukoc Biol,2021,110(6):1113-1120. doi: 10.1002/JLB.3MA0121-024RRRR

[51]

KOOPMAN F A, SCHUURMAN P R, VERVOORDELDONK M J, et al. Vagus nerve stimulation: a new bioelectronics approach to treat rheumatoid arthritis? Best Pract Res Clin Rheumatol,2014,28(4):625-635. doi: 10.1016/j.berh.2014.10.015

[52]

DREWES A M, BROCK C, RASMUSSEN S E, et al. Short-term transcutaneous non-invasive vagus nerve stimulation may reduce disease activity and pro-inflammatory cytokines in rheumatoid arthritis: results of a pilot study[J]. Scand J Rheumatol,2021,50(1):20-27. doi: 10.1080/03009742.2020.1764617

[53]

COURTIES A, BERENBAUM F, SELLAM J. Vagus nerve stimulation in musculoskeletal diseases[J]. Joint Bone Spine,2021,88(3):105149. doi: 10.1016/j.jbspin.2021.105149

[54]

LV J Q, JI X X, LI Z, et al. The role of the cholinergic anti-inflammatory pathway in autoimmune rheumatic diseases[J]. Scand J Immunol,2021,94(4):e13092.

[55]

ZHOU Y, CHI J W, LV W S, et al. Obesity and diabetes as high-risk factors for severe coronavirus disease 2019 (Covid-19)[J]. Diabetes Metab Res Rev,2021,37(2):e3377.

[56]

KWENANDAR F, JAPAR K V, DAMAY V, et al. Coronavirus disease 2019 and cardiovascular system: a narrative review[J]. Int J Cardiol Heart Vasc,2020,29:100557.

[57]

CHEN N S, ZHOU M, DONG X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study[J]. Lancet,2020,395(10223):507-513. doi: 10.1016/S0140-6736(20)30211-7

[58]

WEI Y F, SHAN L, QIAO L M, et al. Protective effects of Huang-Lian-Jie-du-Tang against polymicrobial Sepsis induced by cecal ligation and puncture in rats[J]. Evid Based Complement Alternat Med,2013,2013:909624.

[59]

XU D Q, LV Y, WANG J S, et al. Deciphering the mechanism of Huang-Lian-Jie-Du-Decoction on the treatment of Sepsis by formula decomposition and metabolomics: enhancement of cholinergic pathways and inhibition of HMGB-1/TLR4/NF-κB signaling[J]. Pharmacol Res,2017,121:94-113. doi: 10.1016/j.phrs.2017.04.016

[60]

REN J L, ZHANG A H, WANG X J. Traditional Chinese medicine for COVID-19 treatment[J]. Pharmacol Res,2020,155:104743. doi: 10.1016/j.phrs.2020.104743

[61]

MAIZEL' E B, ROZENGART E V, KHAKIMOV I U P, et al. Ephedrine, salsoline and cytisine derivatives as substrates and inhibitirs of cholinesterases[J]. Biokhimiia,1978,43(7):1150-1156.

[62]

KINALI M, BEESON D, PITT M C, et al. Congenital myasthenic syndromes in childhood: diagnostic and management challenges[J]. J Neuroimmunol,2008,201-202:6-12. doi: 10.1016/j.jneuroim.2008.06.026

[63]

STAATS P, GIANNAKOPOULOS G, BLAKE J, et al. The use of non-invasive vagus nerve stimulation to treat respiratory symptoms associated with COVID-19: a theoretical hypothesis and early clinical experience[J]. Neuromodulation,2020,23(6):784-788. doi: 10.1111/ner.13172

[64]

LU F, SELAK M, O'CONNOR J, et al. Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis[J]. J Neurol Sci,2000,177(2):95-103. doi: 10.1016/S0022-510X(00)00343-9

[65]

PAVLOV V A, TRACEY K J. The vagus nerve and the inflammatory reflex: linking immunity and metabolism[J]. Nat Rev Endocrinol,2012,8(12):743-754. doi: 10.1038/nrendo.2012.189

[66]

WU J, JIAO Z Y, LI R Z, et al. Cholinergic activation suppresses palmitate-induced macrophage activation and improves acylation stimulating protein resistance in co-cultured adipocytes[J]. Exp Biol Med (Maywood),2017,242(9):961-973. doi: 10.1177/1535370217700522

[67]

NISHIO T, TAURA K, IWAISAKO K, et al. Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis[J]. J Gastroenterol,2017,52(8):965-976. doi: 10.1007/s00535-016-1304-z

[68]

DENG J L, WANG M, GUO Y K, et al. Activation of α7nAChR via vagus nerve prevents obesity-induced insulin resistance via suppressing endoplasmic Reticulum stress-induced inflammation in Kupffer cells[J]. Med Hypotheses,2020,140:109671. doi: 10.1016/j.mehy.2020.109671

[69]

YKI-JÄRVINEN H. Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome[J]. Lancet Diabetes Endocrinol,2014,2(11):901-910. doi: 10.1016/S2213-8587(14)70032-4

[70]

KATSIKI N, MIKHAILIDIS D P, MANTZOROS C S. Non-alcoholic fatty liver disease and dyslipidemia: an update[J]. Metabolism,2016,65(8):1109-1123. doi: 10.1016/j.metabol.2016.05.003

[71]

WOO BAIDAL J A, LAVINE J E. The intersection of nonalcoholic fatty liver disease and obesity[J]. Sci Transl Med,2016,8(323):323rv1.

[72]

BIRKENFELD A L, SHULMAN G I. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes[J]. Hepatology,2014,59(2):713-723. doi: 10.1002/hep.26672

[73]

BUZZETTI E, PINZANI M, TSOCHATZIS E A. The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)[J]. Metabolism,2016,65(8):1038-1048. doi: 10.1016/j.metabol.2015.12.012

[74]

KIMURA K, INABA Y, WATANABE H, et al. Nicotinic alpha-7 acetylcholine receptor deficiency exacerbates hepatic inflammation and fibrosis in a mouse model of non-alcoholic steatohepatitis[J]. J Diabetes Investig,2019,10(3):659-666. doi: 10.1111/jdi.12964

[75]

TING K K, BREW B, GUILLEMIN G. The involvement of astrocytes and kynurenine pathway in Alzheimer's disease[J]. Neurotox Res,2007,12(4):247-262. doi: 10.1007/BF03033908

[76]

O'BRIEN J T, EAGGER S, SYED G M, et al. A study of regional cerebral blood flow and cognitive performance in Alzheimer's disease[J]. J Neurol Neurosurg Psychiatry, 1992, 55(12): 1182-1187. https://pubmed.ncbi.nlm.nih.gov/1479398/https://pubmed.ncbi.nlm.nih.gov/1479398/

[77]

DE LA MONTE S M. Brain insulin resistance and deficiency as therapeutic targets in Alzheimer’s disease[J]. Curr Alzheimer Res,2012,9(1):35-66. doi: 10.2174/156720512799015037

[78]

TOTA S, KAMAT P K, SHUKLA R, et al. Improvement of brain energy metabolism and cholinergic functions contributes to the beneficial effects of silibinin against streptozotocin induced memory impairment[J]. Behav Brain Res,2011,221(1):207-215. doi: 10.1016/j.bbr.2011.02.041

[79]

HOYER S. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease[J]. Eur J Pharmacol,2004,490(1-3):115-125. doi: 10.1016/j.ejphar.2004.02.049

[80]

ZEEVALK G D, BERNARD L P, SINHA C, et al. Excitotoxicity and oxidative stress during inhibition of energy metabolism[J]. Dev Neurosci,1998,20(4-5):444-453. doi: 10.1159/000017342

[81]

NAVARRO E, GONZALEZ-LAFUENTE L, PÉREZ-LIÉBANA I, et al. Heme-oxygenase I and PCG-1α regulate mitochondrial biogenesis via microglial activation of Alpha7 nicotinic acetylcholine receptors using PNU282987[J]. Antioxid Redox Signal,2017,27(2):93-105. doi: 10.1089/ars.2016.6698

[82]

PLASCHKE K, HOYER S. Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and Hippocampus[J]. Int J Dev Neurosci,1993,11(4):477-483. doi: 10.1016/0736-5748(93)90021-5

[83]

PATHAN A R, VISWANAD B, SONKUSARE S K, et al. Chronic administration of pioglitazone attenuates intrace-rebroventricular streptozotocin induced-memory impairment in rats[J]. Life Sci,2006,79(23):2209-2216. doi: 10.1016/j.lfs.2006.07.018

[84]

RAJASEKAR N, NATH C, HANIF K, et al. Intranasal insulin improves cerebral blood flow, Nrf-2 expression and BDNF in STZ (ICV)-induced memory impaired rats[J]. Life Sci,2017,173:1-10. doi: 10.1016/j.lfs.2016.09.020

[85]

RAJASEKAR N, DWIVEDI S, NATH C, et al. Protection of streptozotocin induced insulin receptor dysfunction, neuroinflammation and amyloidogenesis in astrocytes by insulin[J]. Neuropharmacology,2014,86:337-352. doi: 10.1016/j.neuropharm.2014.08.013