[1] 严永清. 中药辞海. 第二卷 [M]. 中药辞海. 第二卷, 1996.
[2] 郑维全, 杨建峰, 鱼欢, 等. 我国胡椒产业现状与创新发展探析[J]. 热带农业科学, 2017, 37(12):102-8.
[3] TAKOOREE H, AUMEERUDDY M Z, RENGASAMY K R R, et al. A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications[J]. Critical Reviews in Food Science and Nutrition, 2019, 59(sup1):S210-S43. doi:  10.1080/10408398.2019.1565489
[4] 于岚, 郝正一, 胡晓璐, 等. 胡椒的化学成分与药理作用研究进展[J]. 中国实验方剂学杂志, 2020, 26(6):9.
[5] GORGANI L, MOHAMMADI M, NAJAFPOUR G D, et al. Piperine—The Bioactive Compound of Black Pepper: From Isolation to Medicinal Formulations[J]. Comprehensive Reviews in Food Science and Food Safety, 2017, 16(1):124-40. doi:  10.1111/1541-4337.12246
[6] YUN Y S, SACHIETAKAHASHI, SHIGERUTAKAHASHI, YUJIINOUE, HIDESHI. Piperine-like alkamides from Piper nigrum induce BDNF promoter and promote neurite outgrowth in Neuro-2a cells[J]. Journal of natural medicines, 2018, 72(1):238-45. doi:  10.1007/s11418-017-1140-3
[7] LIU H L, LUO R, CHEN X Q, et al. Identification and simultaneous quantification of five alkaloids in Piper longum L. by HPLC-ESI-MS(n) and UFLC-ESI-MS/MS and their application to Piper nigrum L[J]. Food Chemistry, 2015, 177(jun.15):191-6.
[8] TU Y, ZHONG Y, DU H, et al. Anticholinesterases and antioxidant alkamides from Piper nigrum fruits[J]. Natural Product Research, 2016, 30(17):1945-9. doi:  10.1080/14786419.2015.1089243
[9] PEI H, XUE L, TANG M, et al. Alkaloids from Black Pepper (Piper nigrum L.) Exhibit Anti-Inflammatory Activity in Murine Macrophages by Inhibiting Activation of NF-κB Pathway[J]. Journal of Agricultural and Food Chemistry, 2020, 68(8):2406-17. doi:  10.1021/acs.jafc.9b07754
[10] SUN C, PEI S, PAN Y, et al. Rapid structural determination of amides in Piper longum by high-performance liquid chromatography combined with ion trap mass spectrometry[J]. Rapid Communications in Mass Spectrometry, 2007, 21(9):1497-503. doi:  10.1002/rcm.2986
[11] R. B L, CORINNA D, MADELINE B, et al. The Effect of Pungent and Tingling Compounds from Piper nigrum L. on Background K+ Currents [J]. Frontiers in Pharmacology, 2017, 8: 408.
[12] NGO Q M T, TRAN P T, TRAN M H, et al. Alkaloids from Piper nigrum Exhibit Antiinflammatory Activity via Activating the Nrf2/HO1 Pathway[J]. Phytotherapy Research, 2017, 31(4):663-70. doi:  10.1002/ptr.5780
[13] SRIWIRIYAJAN S, SUKPONDMA Y, SRISAWAT T, et al. (−)-Kusunokinin and piperloguminine from Piper nigrum: An alternative option to treat breast cancer[J]. Biomedicine & Pharmacotherapy, 2017, 92:732-43.
[14] NICOLUSSI S, VIVEROS-PAREDES J M, GACHET M S, et al. Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice[J]. Pharmacological Research, 2014, 80:52-65. doi:  10.1016/j.phrs.2013.12.010
[15] YU L, HU X, XU R, et al. Amide alkaloids characterization and neuroprotective properties of Piper nigrum L.: A comparative study with fruits, pericarp, stalks and leaves[J]. Food Chemistry, 2022, 368:130832. doi:  10.1016/j.foodchem.2021.130832
[16] 王勇, 魏娜, 李洪福, 等. 海南黑胡椒超临界萃取物中化学成分的GC-MS分析[J]. 中国实验方剂学杂志, 2013, 19(12):121-3.
[17] FUJIWARA Y, NAITHOU K, MIYAZAKI T, et al. Two new alkaloids, pipercyclobutanamides A and B, from Piper nigrum[J]. Tetrahedron Letters, 2001, 42(13):2497-9. doi:  10.1016/S0040-4039(01)00209-X
[18] HUU D M N, DANG P H, HUYNH N V, et al. Pipercyclobutanamide D, a new member of the cyclobutanamide-type alkaloid, from the roots of Piper nigrum[J]. Journal of Asian Natural Products Research, 2021, 23(9):906-12. doi:  10.1080/10286020.2020.1794858
[19] 段梦雅, 王福清, 吴桂苹, 等. 4种胡椒精油风味特征分析[J]. 食品科学, 2022(008):043.
[20] BUTT M S, PASHA I, SULTAN M T, et al. Black Pepper and Health Claims: A Comprehensive Treatise[J]. Critical Reviews in Food Science and Nutrition, 2013, 53(9):875-86. doi:  10.1080/10408398.2011.571799
[21] AZIZ N S, SOFIAN-SENG N-S, MOHD RAZALI N S, et al. A review on conventional and biotechnological approaches in white pepper production[J]. Journal of the Science of Food and Agriculture, 2019, 99(6):2665-76. doi:  10.1002/jsfa.9481
[22] 姜太玲, 沈绍斌, 张林辉, 等. 胡椒的化学成分 生理功能及应用研究进展[J]. 农产品加工:下, 2018(1):4.
[23] RENJIE L, SHIDI S, YONGJUN M. Analysis of volatile oil composition of the peppers from different production areas[J]. Medicinal Chemistry Research, 2010, 19(2):157-65. doi:  10.1007/s00044-009-9180-1
[24] CHUNG H Y, JUNG H J, KIM D H, et al. Anti-inflammatory and antioxidant activities of piperine on t-BHP-induced in Ac2F cells [J]. 2019.
[25] VIJAYAKUMAR R S, NALINI N. Piperine, an Active Principle from Piper Nigrum, Modulates Hormonal and Apolipoprotein Profiles in Hyperlipidemic Rats[J]. Journal of Basic and Clinical Physiology and Pharmacology, 2006, 17(2):71-86. doi:  10.1515/JBCPP.2006.17.2.71
[26] BRAHMANAIDU P, NEMANI H, MERIGA B, et al. Mitigating efficacy of piperine in the physiological derangements of high fat diet induced obesity in Sprague Dawley rats[J]. Chemico-Biological Interactions, 2014, 221:42-51. doi:  10.1016/j.cbi.2014.07.008
[27] REYNOSO MORENO I, NAJAR-GUERRERO I, ESCARENO N, et al. An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice [J]. Journal of Agricultural & Food Chemistry, 2017: 9435.
[28] RATHER R A, BHAGAT M. Cancer Chemoprevention and Piperine: Molecular Mechanisms and Therapeutic Opportunities [J]. Frontiers in Cell and Developmental Biology, 2018, 6.
[29] YAFFE P B, POWER COOMBS M R, DOUCETTE C D, et al. Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via G1 arrest and apoptosis triggered by endoplasmic reticulum stress[J]. Molecular Carcinogenesis, 2015, 54(10):1070-85. doi:  10.1002/mc.22176
[30] HAN S Z, LIU H X, YANG L Q, et al. Piperine (PP) enhanced mitomycin-C (MMC) therapy of human cervical cancer through suppressing Bcl-2 signaling pathway via inactivating STAT3/NF-κB[J]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, 96:1403-10.
[31] GUNASEKARAN V, ELANGOVAN K, NIRANJALI DEVARAJ S. Targeting hepatocellular carcinoma with piperine by radical-mediated mitochondrial pathway of apoptosis: An invitro and invivo study[J]. Food and Chemical Toxicology, 2017, 105:106-18. doi:  10.1016/j.fct.2017.03.029
[32] TURRINI E, SESTILI P, FIMOGNARI C. Overview of the anticancer potential of the “king of spices” piper nigrum and its main constituent piperine[J]. Toxins, 2020, 12(12):747. doi:  10.3390/toxins12120747
[33] MATSUDA H, NINOMIYA K, MORIKAWA T, et al. Protective effects of amide constituents from the fruit of Piper chaba on d-galactosamine/TNF-α-induced cell death in mouse hepatocytes[J]. Bioorganic & Medicinal Chemistry Letters, 2008, 18(6):2038-42.
[34] SABINA E P, SOURIYAN A D H, JACKLINE D, et al. Piperine, an active ingredient of black pepper attenuates acetaminophen–induced hepatotoxicity in mice[J]. Asian Pacific Journal of Tropical Medicine, 2010, 3(12):971-6. doi:  10.1016/S1995-7645(11)60011-4
[35] CHOI S, CHOI Y, CHOI Y, et al. Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice[J]. Food Chemistry, 2013, 141(4):3627-35. doi:  10.1016/j.foodchem.2013.06.028
[36] YOUNIS N. Protective mechanisms of piperine against acetaminophen-induced hepatotoxicity may be mediated through TGFBRAP1[J]. European review for medical and pharmacological sciences, 2020, 24:10169-80.
[37] SAMRA Y A, SAID H S, ELSHERBINY N M, et al. Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-κB and NLRP3 inflammasome [J]. Life Sciences, 2016: S0024320516303484.
[38] BOORANASUBKAJORN S, HUABPRASERT S, WATTANARANGSAN J, et al. Vasculoprotective and vasodilatation effects of herbal formula (Sahatsatara) and piperine in spontaneously hypertensive rats[J]. Phytomedicine, 2017, 24:148-56. doi:  10.1016/j.phymed.2016.11.013
[39] MURTAZA A, REHMAN T, ZAFAR Z, et al. Synthesis and Characterization of Herbal Nano-suspensions and Evaluation of their In-vivo Antihypertensive Potential with Especial Focus on Piperine [J]. Journal of Pharmaceutical Research International, 2020.
[40] CHAUDHARY, KUMAR S, MUKHERJEE P K, et al. Evaluation of angiotensin converting enzyme inhibition and anti-oxidant activity of Piper longum L; proceedings of the Lattice Gauge Theories Supersymmetry & Grand Unification Johns Hopkins Workshop on Current Problems in Particle Theory, F, 2013 [C
[41] MAO Q-Q, HUANG Z, ZHONG X-M, et al. Brain-derived neurotrophic factor signalling mediates the antidepressant-like effect of piperine in chronically stressed mice[J]. Behavioural Brain Research, 2014, 261:140-5. doi:  10.1016/j.bbr.2013.12.020
[42] LUCIAN, HRITCU, A J, et al. Anxiolytic and antidepressant profile of the methanolic extract of Piper nigrum fruits in beta-amyloid (1-42) rat model of Alzheimer's disease [J]. Behavioral and brain functions : BBF, 2015.
[43] KHOM S, STROMMER B, SCHöFFMANN A, et al. GABAA receptor modulation by piperine and a non-TRPV1 activating derivative[J]. Biochemical Pharmacology, 2013, 85(12):1827-36. doi:  10.1016/j.bcp.2013.04.017
[44] MAO K, LEI D, ZHANG H, et al. Anticonvulsant effect of piperine ameliorates memory impairment, inflammation and oxidative stress in a rat model of pilocarpine-induced epilepsy[J]. Exp Ther Med, 2017, 13(2):695-700. doi:  10.3892/etm.2016.4001
[45] SUBEDEE L, SURESH R N, JAYANTHI M K, et al. Preventive role of Indian black pepper in animal models of Alzheimer's disease[J]. Journal of Clinical & Diagnostic Research Jcdr, 2015, 9(4):FF01.
[46] CHONPATHOMPIKUNLERT P, WATTANATHORN J, MUCHIMAPURA S. Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease [J]. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, 48: 798-802.
[47] 赵贤武, 黄丽平, 邓敏贞, 等. 高良姜、胡椒和槟榔有效成分对岗田酸诱导p-tau细胞模型的作用研究[J]. 中医学报, 2017, 32(11):5.
[48] 邹兰, 胡月英, 陈文学. 黑胡椒提取物对枯草芽孢杆菌生理代谢的影响[J]. 食品工业科技, 2015, 36(23):4.
[49] 邹兰, 胡月英, 陈文学. 黑胡椒石油醚相提取物对大肠杆菌和金黄色葡萄球菌的抑菌机制研究[J]. 食品科技, 2018, 43(6):5.
[50] FREIRE-DE-LIMA L, RIBEIRO T, ROCHA G, et al. The toxic effects of piperine against Trypanosoma cruzi: Ultrastructural alterations and reversible blockage of cytokinesis in epimastigote forms[J]. Parasitology research, 2008, 102:1059-67. doi:  10.1007/s00436-008-0876-9
[51] CHOUHAN G, ISLAMUDDIN M, WANT M Y, et al. Leishmanicidal Activity of Piper nigrum Bioactive Fractions is Interceded via Apoptosis In Vitro and Substantiated by Th1 Immunostimulatory Potential In Vivo [J]. Frontiers in Microbiology, 2015, 6.
[52] SAMUEL M, OLIVER S V, COETZEE M, et al. The larvicidal effects of black pepper (Piper nigrum L.) and piperine against insecticide resistant and susceptible strains of Anopheles malaria vector mosquitoes[J]. Parasites & Vectors, 2016, 9(1):238.
[53] TAQVI S I H, SHAH A J, GILANI A H. Insight into the possible mechanism of antidiarrheal and antispasmodic activities of piperine [J]. Pharmaceutical Biology.
[54] SMILKOV K, ACKOVA D G, CVETKOVSKI A, et al. Piperine: Old Spice and New Nutraceutical?[J]. Curr Pharm Des, 2019, 25(15):1729-39. doi:  10.2174/1381612825666190701150803
[55] CHATTERJEE S, NIAZ Z, GAUTAM S, et al. Antioxidant activity of some phenolic constituents from green pepper (Piper nigrum L.) and fresh nutmeg mace (Myristica fragrans)[J]. Food Chemistry, 2007, 101(2):515-23. doi:  10.1016/j.foodchem.2006.02.008