[1] GARRIDO-CASTRO A C, WINER E P. Predicting breast cancer therapeutic response[J]. Nat Med,2018,24(5):535-537. doi:  10.1038/s41591-018-0033-7
[2] KROP I, ISMAILA N, ANDRE F, et al. Use of biomarkers to guide decisions on adjuvant systemic therapy for women with early-stage invasive breast cancer: American Society Of Clinical Oncology Clinical Practice Guideline focused update[J]. J Clin Oncol,2017,35(24):2838-2847. doi:  10.1200/JCO.2017.74.0472
[3] SAVAS P, SALGADO R, DENKERT C, et al. Clinical relevance of host immunity in breast cancer: from TILs to the clinic[J]. Nat Rev Clin Oncol,2016,13(4):228-241. doi:  10.1038/nrclinonc.2015.215
[4] VAN 'T VEER L J, DAI H Y, VAN DE VIJVER M J, et al. Gene expression profiling predicts clinical outcome of breast cancer[J]. Nature,2002,415(6871):530-536. doi:  10.1038/415530a
[5] BROWN L C, SALGADO R, LUEN S J, et al. Tumor-infiltrating lymphocyctes in triple-negative breast cancer: update for 2020[J]. Cancer J,2021,27(1):25-31. doi:  10.1097/PPO.0000000000000501
[6] INCORVAIA L, FANALE D, BONO M, et al. BRCA1/2 pathogenic variants in triple-negative versus luminal-like breast cancers: genotype-phenotype correlation in a cohort of 531 patients[J]. Ther Adv Med Oncol, 2020, 12: 1758835920975326.
[7] ZACKSENHAUS E, SHRESTHA M, LIU J C, et al. Mitochondrial OXPHOS induced by RB1 deficiency in breast cancer: implications for anabolic metabolism, stemness, and metastasis[J]. Trends Cancer,2017,3(11):768-779. doi:  10.1016/j.trecan.2017.09.002
[8] LORD S R, CHENG W C, LIU D, et al. Integrated pharmacodynamic analysis identifies two metabolic adaption pathways to metformin in breast cancer[J]. Cell Metab,2018,28(5):679-688.e4. doi:  10.1016/j.cmet.2018.08.021
[9] ICARD P, LOI M, WU Z R, et al. Metabolic strategies for inhibiting cancer development[J]. Adv Nutr,2021:nmaa174.
[10] FLORY J, LIPSKA K. Metformin for type 2 diabetes-reply[J]. JAMA,2019,322(13):1313.
[11] SCHULTEN H J. Pleiotropic effects of metformin on cancer[J]. Int J Mol Sci,2018,19(10):E2850. doi:  10.3390/ijms19102850
[12] CIOCE M, PULITO C, STRANO S, et al. Metformin: metabolic rewiring faces tumor heterogeneity[J]. Cells,2020,9(11):E2439. doi:  10.3390/cells9112439
[13] DYKENS J A, JAMIESON J, MARROQUIN L, et al. Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro[J]. Toxicol Appl Pharmacol,2008,233(2):203-210. doi:  10.1016/j.taap.2008.08.013
[14] ENIA G, GAROZZO M, ZOCCALI C. Lactic acidosis induced by phenformin is still a public health problem in Italy[J]. BMJ,1997,315(7120):1466-1467. doi:  10.1136/bmj.315.7120.1466
[15] GARCÍA RUBIÑO M E, CARRILLO E, RUIZ ALCALÁ G, et al. Phenformin as an anticancer agent: challenges and prospects[J]. Int J Mol Sci,2019,20(13):E3316. doi:  10.3390/ijms20133316
[16] BERNIER G M, MILLER M, SPRINGATE C S. Lactic acidosis and phenformin hydrochloride[J]. JAMA,1963,184:43-46.
[17] KONG H, RECZEK C R, MCELROY G S, et al. Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species[J]. Sci Adv,2020,6(45):eabb7272. doi:  10.1126/sciadv.abb7272
[18] MASOUD R, REYES-CASTELLANOS G, LAC S, et al. Targeting mitochondrial complex I overcomes chemoresistance in high OXPHOS pancreatic cancer[J]. Cell Rep Med,2020,1(8):100143. doi:  10.1016/j.xcrm.2020.100143
[19] OWEN M R, DORAN E, HALESTRAP A P. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain[J]. Biochem J, 2000, 348(Pt 3): 607-614.
[20] FEARNLEY G R, CHAKRABARTI R, EVANS J F. Effect of ethyloestrenol combined with phenformin or with metformin on platelet stickiness and serum-cholesterol in patients with occlusive vascular disease[J]. Lancet,1968,2(7576):1004-1007.
[21] SHACKELFORD D B, ABT E, GERKEN L, et al. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin[J]. Cancer Cell,2013,23(2):143-158. doi:  10.1016/j.ccr.2012.12.008
[22] DI MAGNO L, MANNI S, DI PASTENA F, et al. Phenformin inhibits hedgehog-dependent tumor growth through a complex I-independent redox/corepressor module[J]. Cell Rep,2020,30(6):1735-1752. doi:  10.1016/j.celrep.2020.01.024