[1] MATIJAŠIĆ M, MEŠTROVIĆ T, PALJETAK H Č, et al. Gut microbiota beyond bacteria-mycobiome, virome, archaeome, and eukaryotic parasites in IBD[J]. Int J Mol Sci,2020,21(8):2668. doi:  10.3390/ijms21082668
[2] DENG P, SWANSON K S. Gut microbiota of humans, dogs and cats: current knowledge and future opportunities and challenges[J]. Br J Nutr,2015,113(Suppl):S6-S17.
[3] CLARKE G, STILLING R M, KENNEDY P J, et al. Minireview: Gut microbiota: the neglected endocrine organ[J]. Mol Endocrinol,2014,28(8):1221-1238. doi:  10.1210/me.2014-1108
[4] SHI Q W, DAI L L, ZHAO Q, et al. A review on the effect of gut microbiota on metabolic diseases[J]. Arch Microbiol,2022,204(3):1-6.
[5] DING M Q, LANG Y, SHU H, et al. Microbiota-gut-brain axis and epilepsy: a review on mechanisms and potential therapeutics[J]. Front Immunol,2021,12:742449. doi:  10.3389/fimmu.2021.742449
[6] 赵净颖, 段小花, 王秋婷, 等. 动物骨代谢相关信号通路研究进展[J]. 遗传, 2020, 42(10):979-992. doi:  10.16288/j.yczz.20-066
[7] ZHANG J, LU Y Q, WANG Y Z, et al. The impact of the intestinal microbiome on bone health[J]. Intractable Rare Dis Res,2018,7(3):148-155. doi:  10.5582/irdr.2018.01055
[8] FLEET J C. The role of vitamin D in the endocrinology controlling calcium homeostasis[J]. Mol Cell Endocrinol,2017,453:36-45. doi:  10.1016/j.mce.2017.04.008
[9] HANG S Y, PAIK D, YAO L N, et al. Bile acid metabolites control TH17 and Treg cell differentiation[J]. Nature,2019,576(7785):143-148. doi:  10.1038/s41586-019-1785-z
[10] SONG X Y, SUN X M, OH S F, et al. Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis[J]. Nature,2020,577(7790):410-415. doi:  10.1038/s41586-019-1865-0
[11] RODRÍGUEZ V, RIVOIRA M, MARCHIONATTI A, et al. Ursodeoxycholic and deoxycholic acids: a good and a bad bile acid for intestinal calcium absorption[J]. Arch Biochem Biophys,2013,540(1-2):19-25. doi:  10.1016/j.abb.2013.09.018
[12] LUCAS S, OMATA Y, HOFMANN J, et al. Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss[J]. Nat Commun,2018,9(1):55. doi:  10.1038/s41467-017-02490-4
[13] DE MARTINIS M, GINALDI L, ALLEGRA A, et al. The osteoporosis/microbiota linkage: the role of miRNA[J]. Int J Mol Sci,2020,21(23):8887. doi:  10.3390/ijms21238887
[14] WANG Y, WU Y P, WANG Y Y, et al. Antioxidant properties of probiotic bacteria[J]. Nutrients,2017,9(5):521. doi:  10.3390/nu9050521
[15] DOMAZETOVIC V, MARCUCCI G, IANTOMASI T, et al. Oxidative stress in bone remodeling: role of antioxidants[J]. Clin Cases Miner Bone Metab,2017,14(2):209-216. doi:  10.11138/ccmbm/2017.14.1.209
[16] SJÖGREN K, ENGDAHL C, HENNING P, et al. The gut microbiota regulates bone mass in mice[J]. J Bone Miner Res,2012,27(6):1357-1367. doi:  10.1002/jbmr.1588
[17] NAGANO Y, ITOH K, HONDA K. The induction of Treg cells by gut-indigenous Clostridium[J]. Curr Opin Immunol,2012,24(4):392-397. doi:  10.1016/j.coi.2012.05.007
[18] SYRBE U, SIEGMUND B. Bone marrow Th17 TNFα cells induce osteoclast differentiation and link bone destruction to IBD[J]. Gut,2015,64(7):1011-1012. doi:  10.1136/gutjnl-2014-308436
[19] LUO C Y, WANG L, SUN C, et al. Estrogen enhances the functions of CD4(+)CD25(+)Foxp3(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro[J]. Cell Mol Immunol,2011,8(1):50-58. doi:  10.1038/cmi.2010.54
[20] LUU M, WEIGAND K, WEDI F, et al. Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate[J]. Sci Rep,2018,8(1):14430. doi:  10.1038/s41598-018-32860-x
[21] DONKOR O N, RAVIKUMAR M, PROUDFOOT O, et al. Cytokine profile and induction of T helper type 17 and regulatory T cells by human peripheral mononuclear cells after microbial exposure[J]. Clin Exp Immunol,2012,167(2):282-295. doi:  10.1111/j.1365-2249.2011.04496.x
[22] OKUMURA R, TAKEDA K. Roles of intestinal epithelial cells in the maintenance of gut homeostasis[J]. Exp Mol Med,2017,49(5):e338. doi:  10.1038/emm.2017.20
[23] KE K, CHEN T H, ARRA M, et al. Attenuation of NF-κB in intestinal epithelial cells is sufficient to mitigate the bone loss comorbidity of experimental mouse colitis[J]. J Bone Miner Res,2019,34(10):1880-1893. doi:  10.1002/jbmr.3759
[24] WANG N, MA S C, FU L J. Gut microbiota dysbiosis as one cause of osteoporosis by impairing intestinal barrier func-tion[J]. Calcif Tissue Int,2022,110(2):225-235. doi:  10.1007/s00223-021-00911-7
[25] QI X Y, YUN C Y, PANG Y L, et al. The impact of the gut microbiota on the reproductive and metabolic endocrine system[J]. Gut Microbes,2021,13(1):1-21.
[26] THOMASIUS F, HADJI P. Influence of hormone or hormone replacement therapy on bone healing[J]. Unfallchirurg,2019,122(7):512-517. doi:  10.1007/s00113-019-0677-x
[27] MA S C, QIN J H, HAO Y Q, et al. Structural and functional changes of gut microbiota in ovariectomized rats and their correlations with altered bone mass[J]. Aging (Albany NY),2020,12(11):10736-10753.
[28] 黄俊俊, 史晓林, 邓祖跃. 强骨饮联合益生菌对大鼠骨质疏松性骨折的愈合作用[J]. 中国现代应用药学, 2019, 36(7):791-795. doi:  10.13748/j.cnki.issn1007-7693.2019.07.004
[29] KHOSLA S. The microbiome adds to the complexity of parathyroid hormone action on bone[J]. J Clin Invest,2020,130(4):1615-1617. doi:  10.1172/JCI135712
[30] YU M C, MALIK TYAGI A, LI J Y, et al. PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells[J]. Nat Commun,2020,11(1):468. doi:  10.1038/s41467-019-14148-4
[31] LI J Y, YU M C, PAL S, et al. Parathyroid hormone-dependent bone formation requires butyrate production by intestinal microbiota[J]. J Clin Invest,2020,130(4):1767-1781. doi:  10.1172/JCI133473
[32] YAN J, CHARLES J F. Gut Microbiota and IGF-1[J]. Calcif Tissue Int,2018,102(4):406-414. doi:  10.1007/s00223-018-0395-3
[33] SCHWARZER M, MAKKI K, STORELLI G, et al. Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition[J]. Science,2016,351(6275):854-857. doi:  10.1126/science.aad8588
[34] YAN J, HERZOG J W, TSANG K, et al. Gut microbiota induce IGF-1 and promote bone formation and growth[J]. Proc Natl Acad Sci U S A,2016,113(47):E7554-E7563.
[35] YANO J M, YU K, DONALDSON G P, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis[J]. Cell,2015,161(2):264-276. doi:  10.1016/j.cell.2015.02.047
[36] REIGSTAD C S, SALMONSON C E, RAINEY J F 3rd, et al. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells[J]. FASEB J,2015,29(4):1395-1403. doi:  10.1096/fj.14-259598
[37] YADAV V K, BALAJI S, SURESH P S, et al. Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis[J]. Nat Med,2010,16(3):308-312. doi:  10.1038/nm.2098
[38] KODE A, MOSIALOU I, SILVA B C, et al. FOXO1 orchestrates the bone-suppressing function of gut-derived seroton-in[J]. J Clin Invest,2012,122(10):3490-3503. doi:  10.1172/JCI64906
[39] 葛继荣, 王和鸣, 郑洪新, 等. 中医药防治原发性骨质疏松症专家共识(2020)[J]. 中国骨质疏松杂志, 2020, 26(12):1717-1725. doi:  10.3969/j.issn.1006-7108.2020.12.001
[40] JIA X, JIA L, MO L, et al. Berberine ameliorates periodontal bone loss by regulating gut microbiota[J]. J Dent Res,2019,98(1):107-116. doi:  10.1177/0022034518797275
[41] LI B, LIU M Y, WANG Y, et al. Puerarin improves the bone micro-environment to inhibit OVX-induced osteoporosis via modulating SCFAs released by the gut microbiota and repairing intestinal mucosal integrity[J]. Biomedecine Pharmacother,2020,132:110923. doi:  10.1016/j.biopha.2020.110923
[42] 冯澜, 李绍民, 代立娟, 等. 马齿苋多糖对溃疡性结肠炎小鼠肠黏膜细胞因子及肠道菌群的影响[J]. 中国微生态学杂志, 2015, 27(2):139-142.
[43] KIM J Y, OH H M, KWAK S C, et al. Purslane suppresses osteoclast differentiation and bone resorbing activity via inhibition of Akt/GSK3β-c-Fos-NFATc1 signaling in vitro and prevents lipopolysaccharide-induced bone loss in vivo[J]. Biol Pharm Bull,2015,38(1):66-74. doi:  10.1248/bpb.b14-00567
[44] 吕南宁, 张浩, 冯骁骁, 等. 淫羊藿苷干预骨质疏松的研究进展[J]. 江苏大学学报(医学版), 2022, 32(1):22-25. doi:  10.13312/j.issn.1671-7783.y210086
[45] WANG S S, WANG S J, WANG X N, et al. Effects of icariin on modulating gut microbiota and regulating metabolite alterations to prevent bone loss in ovariectomized rat model[J]. Front Endocrinol (Lausanne),2022,13:874849. doi:  10.3389/fendo.2022.874849
[46] 郭鱼波, 马如风, 王丽丽, 等. 女贞子治疗骨质疏松作用及其机制的研究进展[J]. 中草药, 2016, 47(5):851-856.
[47] CHEN B B, WEI J P, ZHU R Y, et al. Fructus Ligustri Lucidi aqueous extract promotes calcium balance and short-chain fatty acids production in ovariectomized rats[J]. J Ethnopharmacol,2021,279:114348. doi:  10.1016/j.jep.2021.114348
[48] 高宏伟, 李玉萍, 李守超. 杜仲的化学成分及药理作用研究进展[J]. 中医药信息, 2021, 38(6):73-81.
[49] ZHAO X, WANG Y J, NIE Z Y, et al. Eucommia ulmoides leaf extract alters gut microbiota composition, enhances short-chain fatty acids production, and ameliorates osteoporosis in the senescence-accelerated mouse P6 (SAMP6) model[J]. Food Sci Nutr,2020,8(9):4897-4906. doi:  10.1002/fsn3.1779
[50] LIU J S, LIU J, LIU L, et al. The gut microbiota alteration and the key bacteria in Astragalus polysaccharides (APS)-improved osteoporosis[J]. Food Res Int, 2020, 138(Pt B): 109811.
[51] VILLA J K D, DIAZ M A N, PIZZIOLO V R, et al. Effect of vitamin K in bone metabolism and vascular calcification: a review of mechanisms of action and evidences[J]. Crit Rev Food Sci Nutr,2017,57(18):3959-3970. doi:  10.1080/10408398.2016.1211616
[52] VAN WIJNGAARDEN J P, DOETS E L, SZCZECIŃSKA A, et al. Vitamin B12, folate, homocysteine, and bone health in adults and elderly people: a systematic review with meta-analyses[J]. J Nutr Metab,2013,2013:486186.
[53] TANG X Y, GAO M X, XIAO H H, et al. Effects of Xian-Ling-Gu-Bao capsule on the gut microbiota in ovariectomized rats: metabolism and modulation[J]. J Chromatogr B Analyt Technol Biomed Life Sci,2021,1176:122771. doi:  10.1016/j.jchromb.2021.122771
[54] 熊梦欣. 基于丁酸介导的AMPK/mTOR/ULK1信号通路探讨补肾化痰方防治绝经后骨质疏松症的机制研究[D]. 武汉: 湖北中医药大学, 2022.
[55] SUN P, ZHANG C T, HUANG Y M, et al. Jiangu Granule ameliorated OVX rats bone loss by modulating gut microbiota-SCFAs-Treg/Th17 axis[J]. Biomedecine Pharmacother,2022,150:112975. doi:  10.1016/j.biopha.2022.112975
[56] 王雅婷, 兰丽珍. 葛根芩连汤治疗糖尿病骨质疏松大鼠的效果及机制[J]. 世界中医药, 2020, 15(12):1724-1728. doi:  10.3969/j.issn.1673-7202.2020.12.010
[57] 王芬, 吴丽丽, 焦婷婷, 等. 葛根芩连汤对KKAy糖尿病小鼠肠道菌群结构的影响[J]. 吉林中医药, 2021, 41(12):1641-1646. doi:  10.13463/j.cnki.jlzyy.2021.12.027
[58] TIAN J X, BAI B B, GAO Z Z, et al. Alleviation effects of GQD, a traditional Chinese medicine formula, on diabetes rats linked to modulation of the gut microbiome[J]. Front Cell Infect Microbiol,2021,11:740236. doi:  10.3389/fcimb.2021.740236