| [1] | SOUCY T A, SMITH P G, MILHOLLEN M A, et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer[J]. Nature,2009,458(7239):732-736 |
| [2] | SWORDS R T, KELLY K R, SMITH P G, et al. Inhibition of NEDD8-activating enzyme: A novel approach for the treatment of acute myeloid leukemia[J]. Blood,2010,115(18):3796-3800 |
| [3] | TANAKA T, NAKATANI T, KAMITANI T. Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy[J]. Mol Oncol,2012,6(3):267-275 |
| [4] | XU B, DENG Y Y, BI R, et al. A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification[J]. Cancer Chemother Pharmacol,2018,81(6):1083-1093 |
| [5] | LU P, GUO Y H, ZHU L J, et al. A novel NAE/UAE dual inhibitor LP0040 blocks neddylation and ubiquitination leading to growth inhibition and apoptosis of cancer cells[J]. Eur J Med Chem,2018,154:294-304 |
| [6] | ZHANG S P, TAN J N, LAI Z H, et al. Effective virtual screening strategy toward covalent ligands: identification of novel NEDD8-activating enzyme inhibitors[J]. J Chem Inf Model,2014,54(6):1785-1797 |
| [7] | ZHONG H J, LEUNG K H, LIN S, et al. Discovery of deoxyvasicinone derivatives as inhibitors of NEDD8-activating enzyme[J]. Methods,2015,71:71-76 |
| [8] | VERMA S, SINGH A, MISHRA A. Molecular dynamics investigation on the poor sensitivity of A171T mutant NEDD8-activating enzyme (NAE) for MLN4924[J]. J Biomol Struct Dyn,2014,32(7):1064-1073 |
| [9] | MIAO Z Y, ZHU L J, DONG G Q, et al. A new strategy to improve the metabolic stability of lactone: discovery of (20S, 21S)-21-fluorocamptothecins as novel, hydrolytically stable topoisomerase I inhibitors[J]. J Med Chem,2013,56(20):7902-7910 |
| [10] | WU K J, ZHONG H J, LI G D, et al. Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing[J]. Eur J Med Chem,2018,143:1021-1027 |
| [11] | LEE H W, NAM S K, CHOI W J, et al. Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme[J]. J Org Chem,2011,76(9):3557-3561 |