[1] Nielsen J. Systems Biology of Metabolism[J]. Annu Rev Biochem, 2017, 86:245-275.
[2] Fiehn O. Metabolomics-the link between genotypes and phenotypes[J]. Plant Mol Biol, 2002, 48(1-2):155-171.
[3] Karahalil B. Overview of Systems Biology and Omics Technologies[J]. Curr Med Chem, 2016, 23(37):4221-4230.
[4] Petersson SV, Lindén P, Moritz T,et al. Cell-type specific metabolic profiling of Arabidopsis thaliana protoplasts as a tool for plant systems biology[J]. Metabolomics, 2015, 11(6):1679-1689.
[5] Danielsson AP, Moritz T, Mulder H,et al. Development and optimization of a metabolomic method for analysis of adherent cell cultures[J]. Anal Biochem, 2010, 404(1):30-39.
[6] Wolfender JL, Glauser G, Boccard J,et al. MS-based plant metabolomic approaches for biomarker discovery[J]. Nat Prod Commun, 2009, 4(10):1417-1430.
[7] Ramautar R, Somsen GW, de Jong G J. CE-MS for metabolomics:Developments and applications in the period 2014-2016[J]. Electrophoresis, 2017, 38(1):190-202.
[8] Tohge T, Fernie AR. Combining genetic diversity, informatics and metabolomics to facilitate annotation of plant gene function[J]. Nat Protoc, 2010, 5(6):1210-1227.
[9] Ernst M, Silva DB, Silva RR,et al. Mass spectrometry in plant metabolomics strategies:from analytical platforms to data acquisition and processing[J]. Nat Prod Rep, 2014, 31(6):784-806.
[10] Mak TD, Laiakis EC, Goudarzi M,et al. MetaboLyzer:a novel statistical workflow for analyzing Postprocessed LC-MS metabolomics data[J]. Anal Chem, 2014, 86(1):506-513.
[11] Culibrk L, Croft CA, Tebbutt SJ, et al. Systems Biology Approaches for Host-Fungal Interactions:An Expanding Multi-Omics Frontier[J]. OMICS, 2016, 20(3):127-138.
[12] Wan JY, Liu P, Wang HY, et al. Biotransformation and metabolic profile of American ginseng saponins with human intestinal microflora by liquid chromatography quadrupole time-of-flight mass spectrometry[J]. J Chromatogr A, 2013, 1286:83-92.
[13] Kim N, Kim K, Lee D,et al. Nontargeted metabolomics approach for age differentiation and structure interpretation of age-dependent key constituents in hairy roots of Panax ginseng[J]. J Nat Prod, 2012, 75(10):1777-1784.
[14] Park HE, Lee SY, Hyun SH,et al. Gas chromatography/mass spectrometry-based metabolic profiling and differentiation of ginseng roots according to cultivation age using variable selection[J]. J AOAC Int, 2013, 96(6):1266-1272.
[15] Chu C, Xu S, Li X,et al. Profiling the ginsenosides of three ginseng products by LC-Q-TOF/MS[J]. J Food Sci, 2013, 78(5):C653-C659.
[16] Kim SH, Hyun SH, Yang SO,et al. (1)H-NMR-based discrimination of thermal and vinegar treated ginseng roots[J]. J Food Sci, 2010, 75(6):C577-C581.
[17] Lee EJ, Shaykhutdinov R, Weljie AM,et al. Quality assessment of ginseng by (1)H NMR metabolite fingerprinting and profiling analysis[J]. J Agric Food Chem, 2009, 57(16):7513-7522.
[18] Li SL, Song JZ, Choi FF,et al. Chemical profiling of Radix Paeoniae evaluated by ultra-performance liquid chromatography/photo-diode-array/quadrupole time-of-flight mass spectrometry[J]. J Pharm Biomed Anal, 2009, 49(2):253-266.
[19] Montoro P, Maldini M, Piacente S,et al. Metabolite fingerprinting of Camptotheca acuminata and the HPLC-ESI-MS/MS analysis of camptothecin and related alkaloids[J]. J Pharm Biomed Anal, 2010, 51(2):405-415.
[20] Pan Q, Wang Q, Yuan F,et al. Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics[J]. PLoS One, 2012, 7(8):e43038.
[21] Dai H, Xiao C, Liu H,et al. Combined NMR and LC-MS analysis reveals the metabonomic changes in Salvia miltiorrhiza Bunge induced by water depletion[J]. J Proteome Res, 2010, 9(3):1460-1475.
[22] Yamazaki M, Mochida K, Asano T,et al. Coupling deep transcriptome analysis with untargeted metabolic profiling in Ophiorrhiza pumila to further the understanding of the biosynthesis of the anti-cancer alkaloid camptothecin and anthraquinones[J]. Plant Cell Physiol, 2013, 54(5):686-696.
[23] Chen J, Dong X, Li Q,et al. Biosynthesis of the active compounds of Isatis indigotica based on transcriptome sequencing and metabolites profiling[J]. BMC Genomics, 2013, 14(1):857.
[24] Toh DF, New LS, Koh HL,et al. Ultra-high performance liquid chromatography/time-of-flight mass spectrometry (UHPLC/TOFMS) for time-dependent profiling of raw and steamed Panax notoginseng[J]. J Pharm Biomed Anal, 2010, 52(1):43-50.
[25] Bondia-Pons I, Savolainen O, Törrönen R, et al. Metabolic profiling of Goji berry extracts for discrimination of geographical origin by non-targeted liquid chromatography coupled to quadrupole time-of-flight massspectrometry[J]. Food Res Int, 2014, 63:132-138.
[26] Duan LX, Chen TL, Li M,et al. Use of the metabolomics approach to characterize Chinese medicinal material Huangqi[J]. Mol Plant, 2012, 5(2):376-386.
[27] Jung JY, Jung Y, Kim JS,et al. Assessment of peeling of Astragalus roots using 1H NMR-and UPLC-MS-based metabolite profiling[J]. J Agric Food Chem, 2013, 61(43):10398-10407.
[28] Kwon J, Kim N, Lee D,et al. Metabolomics approach for the discrimination of raw and steamed Gastrodia elata using liquid chromatography quadrupole time-of-flight mass spectrometry[J]. J Pharm Biomed Anal, 2014, 94:132-138.
[29] de Oliveira Dal'Molin Cristiana G, Orellana Camila, Gebbie Leigh,et al. Metabolic reconstruction of setaria italica:A systems biology approach for integrating tissue-specific omics and pathway analysis of bioenergy grasses[J]. Front Plant Sci, 2016, 7:1138.
[30] Murch SJ, Rupasinghe HP, Goodenowe D,et al. A metabolomic analysis of medicinal diversity in Huang-qin (Scutellaria baicalensis Georgi) genotypes:discovery of novel compounds[J]. Plant Cell Rep, 2004, 23(6):419-425.
[31] Kim HK, Choi YH, Erkelens C,et al. Metabolic fingerprinting of Ephedra species using 1H-NMR spectroscopy and principal component analysis[J]. Chem Pharm Bull (Tokyo), 2005, 53(1):105-109.
[32] Li SL, Shen H, Zhu LY,et al. Ultra-high-performance liquid chromatography-quadrupole/time of flight mass spectrometry based chemical profiling approach to rapidly reveal chemical transformation of sulfur-fumigated medicinal herbs, a case study on white ginseng[J]. J Chromatogr A, 2012, 1231:31-45.
[33] Lee EJ, Shaykhutdinov R, Weljie AM,et al. Quality assessment of ginseng by1H-NMR metabolite fingerprinting and profiling analysis[J]. J Agric Food Chem, 2009, 57(16):7513-7522.
[34] Winzer T, Gazda V, He Z,et al. A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine[J]. Science, 2012, 336(6089):1704-1708.
[35] Happyana N, Kayser O. Monitoring metabolite profiles of Cannabis sativa L. Trichomes during flowering period using 1H NMR-based metabolomics and real-time PCR[J]. Planta Med, 2016, 82(13):1217-1223.
[36] Jia X, Sun C, Zuo Y,et al. Integrating transcriptomics and metabolomics to characterise the response of Astragalus membranaceus Bge. var. mongolicus (Bge.) to progressive drought stress[J]. BMC Genomics, 2016, 17(1):88.
[37] Guldbrandsen N, Kostidis S, Schäfer H,et al. NMR-based metabolomic study on isatis tinctoria:comparison of different accessions, harvesting dates, and the effect of repeated harvesting[J]. J Nat Prod, 2015, 78(5):977-986.
[38] Goossens A. It is easy to get huge candidate gene lists for plant metabolism now, but how to get beyond?[J]. Mol Plant, 2015, 8(1):2-5.
[39] Tian L, Hu Y, Chen XY. Advancing human health through exploration of plant metabolism and reaping the benefits of edible medicinal plants[J]. Mol Plant, 2017, 10(3):533-536.
[40] Wurtzel ET, Kutchan TM. Plant metabolism, the diverse chemistry set of the future[J]. Science, 2016, 353(6305):1232-1236.