[1] Listed N. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, March 7-29, 2000:highlights of the conference[J]. South Med J, 2001, 94(6):569-573.
[2] Lewiecki EM. New targets for intervention in the treatment of postmenopausal osteoporosis[J]. Nat Rev Rheumatol, 2011, 7(11):631-638.
[3] Riggs BL, Melton LJ Ⅲ. The worldwide problem of osteoporosis:insights afforded by epidemiology[J]. Bone, 1995, 17(5Suppl):505S-511S.
[4] Kanis JA On behalf of the World Health Organization Scientific Group. Assessment of Osteoporosis at the Primary Health-care Level[M].UK:University of Sheffield, 2008.
[5] Kanis JA, Johnell O. Requirements for DXA for the management of osteoporosis in Europe[J]. Osteoporosis Int, 2005, 16(3):229-238.
[6] Burge R, Dawson-Hughes B, Solomon DH, et al. Incidence and economic burden of osteoporosis-related fractures in the United States,2005-2025[J]. J Bone Miner Res,2007, 22(3):465-475.
[7] Cosman F, de Beur SJ, LeBoff MS, et al. Clinician's guide to prevention and treatment of osteoporosis[J]. Osteoporos Int, 2014, 25(10):2359-2381.
[8] Rivadeneira F, Mäkitie O. Osteoporosis and bone mass disorders:from gene pathways to treatments[J]. Trends Endocrinol Metab, 2016, 27(5):262-281.
[9] Seeman E, Delmas PD. Bone quality-the material and structural basis of bone strength and fragility[J]. New Engl J Med, 2008, 26(1):1-8.
[10] Mafi Golchin M, Heidari L, Ghaderian SM, et al. Osteoporosis:a silent disease with complex genetic contribution[J]. Yi chuan xue bao, 2016, 43(2):49-61.
[11] Szabo CM, Martin MB, Oldfield E. An investigation of bone resorption and Dictyostelium discoideum growth inhibition by bisphosphonate drugs[J]. J Med Chem, 2002, 45(14):2894-2903.
[12] Lazar A, Pacurar M, Campian RS. Bisphosphonates in bone diseases treatment[J]. Rev Chimie -Bucharest, 2017, 68(2):246-249.
[13] Stute P, Birkhäuser M. Selektive Östrogenrezep-tormodulatoren (SERM)[J]. Gynäkologische Endokrinologie, 2015, 13(2):126-134.
[14] Evans MF, Frank J. Clinical practice guidelines for the diagnosis and management of osteoporosis[J]. Can Fam Physician, 1997, 43(8):635.
[15] Abdelazim IA, Faza MA, Ayash HM. Effects of Raloxifene hydrochloride on bone mineral density and serum lipids in Kuwaiti postmenopausal women with osteoporosis[J]. Arch Osteoporos, 2015, 4(1):1-5.
[16] Inzerillo AM, Zaidi M, Huang CL. Calcitonin:physiological actions and clinical applications[J]. J Pediatr Endocr Metab, 2004, 17(7):931-940.
[17] Atbinici H, Sipahio lu S, Aksoy N, et al. Effects of salmon calcitonin treatment on serum and synovial fluid bone formation and resorption markers in osteoporosis patients[J]. Acta Orthop Traumatol Turc, 2015, 49(2):160-165.
[18] 马慧萍,贾正平,葛欣,等.骨质疏松症的药物防治研究现状[J],中国药师, 2004, 7(10):816-818.
[19] Bhandari KH, Asghar W, Newa M, et al. Evaluation of bone targeting salmon calcitonin analogues in rats developing osteoporosis and adjuvant arthritis[J]. Curr Drug Deliv, 2015, 12(1):98-107.
[20] Rahnama M, Jastrzebska-Jamrogiewicz I, Jamrogiewicz R, et al. Analysis of the influence of hormone replacement therapy on osteocalcin gene expression in postmenopausal women[J]. Biomed Res Int, 2015, 2015:416929.
[21] Rossini M, Adami G, Adami S, et al. Safety issues and adverse reactions with osteoporosis management[J]. Expert Opin Drug Saf, 2016, 15(3):321-332.
[22] U.S. Preventive Services Task Force. Hormone therapy for the prevention of chronic conditions in postmenopausal women:recommendations from the U.S. Preventive Services Task Force[J]. Ann Intern Med, 2005, 142(10):855-860.
[23] Cranney A, Papaioannou A, Zytaruk N, et al. Parathyroid hormone for the treatment of osteoporosis:a systematic review[J]. CMAJ, 2006, 175(1):52-59.
[24] Hodsman AB, Bauer DC, Dempster DW, et al. Parathyroid hormone and teriparatide for the treatment of osteoporosis:a review of the evidence and suggested guidelines for its use[J]. Endocr Rev, 2005, 26(5):688-703.
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[25] Francis RM, Aspray TJ, Bow