[1] 张晓慧, 杨恩才, 万春平.雷公藤内酯醇及其衍生物的药理作用研究进展[J].云南中医中药杂志,2013,34(8):64-65.
[2] 国家食品药品监督管理总局.药物遗传毒性研究技术指导原则[EB/OL].2007-10-23[2015-11-15].http://www.sda.gov.cn/WS01/CL1616/90936.html.
[3] 周海钧.ICH药品注册的国际技术要求:安全性部分[M].北京:人民卫生出版社,2001:37-61.
[4] OECD. Test Guidance 471:Bacterial Reverse Mutation Test[S]//OECD Guidance For Testing of Chemicals. Paris:Organization for Economic Cooperation & Development,1997:1-8.
[5] OECD. Test Guidance 473:In Vitro Mammalian Chromosome Aberration Test[S]//OECD Guidance for Testing of Chemicals. Paris:Organization for Economic Cooperation & Development, 1997:1-7.
[6] OECD. Test Guidance 474:Mammalian Erythrocyte Micronucleus Test[S]//OECD Guidance for Testing of Chemicals. Paris:Organization for Economic Cooperation & Development,1997:1-7.
[7] 张鹏宇, 张瑞,王雅贤.雷公藤内酯醇抗肿瘤分子机制研究进展[J].中医药学报,2009,37(3):79-82.
[8] Ling D, Xia H, Park W, et al. pH-sensitive nanoformulated triptolide as a targeted therapeutic strategy for hepatocellular carcinoma[J]. ACS Nano, 2014, 8(8):8027-8039.
[9] 吴娜, 刘星雨,王笃军,等.雷公藤内酯醇对C57BL/6小鼠亚慢性毒性作用的研究[J]. 中成药, 2014,36(5):904-908.
[10] 周顺长, 吴越,王兵,等.雷公藤内酯醇聚合物胶束的急性毒性研究[J].医药导报, 2013, 32(12):1563-1565.
[11] Qu L, Qu F, Jia Z, et al. Integrated targeted sphingolipidomics and transcriptomics reveal abnormal sphingolipid metabolism as a novel mechanism of the hepatotoxicity and nephrotoxicity of triptolide[J]. J Ethnopharmacol, 2015, 170:28-38.
[12] 骆永伟, 施畅,原野,等.雷公藤甲素的毒理学研究进展[J]. 毒理学杂志, 2009,23(1):74-77.
[13] Zhang J, Liu L, Mu X, et al. Effect of triptolide on estradiol release from cultured rat granulosa cells[J]. Endocr J, 2012, 59(6):473-481.
[14] Jin J, Sun XZ, Zhao ZX, et al. Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity[J]. Phytomedicine, 2015, 22(10):894-901.
[15] 高涛.雷公藤内酯醇靶蛋白及其药理机制研究进展[J].重庆医学,2012,41(35):3777-3780.
[16] Ho LJ, Chang WL, Chen A, et al. Differential immunomodulatory effects by Tripterygium wilfordii Hook f-derived refined extract PG27 and its purified component PG490(triptolide) in human peripheral blood T cells:potential therapeutics for arthritis and possible mechanisms explaining in part Chinese herbal theory "Junn-Chenn-Zuou-SS"[J]. J Transl Med, 2013, 11:294.
[17] Ma B, Qi HH, Li J, et al. Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury:A GC-MS based metabolomics study[J]. Toxicology, 2015, 336:84-95.
[18] 杨建一, 高宝珍,李莉,等.雷公藤多甙对雄性小鼠生殖细胞毒性的研究[J].癌变·畸变·突变,2008,20(5):393-397.