MDR1基因多态性和单倍体对肾移植术后稳定期患者他克莫司浓度/剂量比值的影响

张燕青; 陈锦珊; 李金雨; 林秀丽; 石鹤坤; 林小凤; 张燕青; 陈锦珊; 李金雨; 林秀丽; 石鹤坤; 林小凤

doi:10.3969/j.issn.1006-0111.2015.05.008

[1]

Margreiter R. Efficacy and safety of tacrolimus compared with ciclosporin microemulsion in renal transplantation: a randomised multicentre study[J]. Lancet,2002,359:741-746.

[2]

Sandrini S, Aslam N, Tardanico R, et al. Tacrolimus versus cyclosporine for early steroid withdrawal after renal transplantation[J]. J Nephrol, 2012, 25(1):43-49.

[3]

Wallemacq P, Armstrong VW, Brunet M, et al. Opportunities to optimize tacrolimus therapy in solid organ transplantation: report of the European Consensus Conference[J].Ther Drug Monit,2009,31(2):139-152.

[4]

Hoffmeyer S,Burk O,Von Richter O,et al. Functional polymorphisms of the human multidrug- resistance gene:multiple sequence variations and correlation of one allele with P- glycoprotein expression and activity in vivo[J]. Proc Natl Acad Sci (USA),2000,97(7):3473-3478.

[5]

曾明,邸晓辉,赵维娟,等. 五酯胶囊(片)对他克莫司血药浓度及药动学参数影响的Meta分析[J].解放军药学学报,2014,30(5):405-409.

[6]

吴雪,蔡林,石姗平,等. 五酯胶囊对肾移植患者他克莫司血药浓度的影响[J].中国药房,2013,24(43):4094-4097.

[7]

刘龙山,王长希,傅茜,等. 五酯片用于肾移植患者对他克莫司药代动力学的影响及长期疗效观察[J]. 器官移植,2012,3(1):33-36.

[8]

胡永芳,周宏灏. CYP3A4,CYP3A5和MDR1基因多态性对环抱素处置的影响[J].中国药理学通报,2005,21(3):257-261.

[9]

李丹滢,方芸. CYP3A4/5、ABCB1基因单倍型与中国肾移植患者他克莫司血药谷浓度相关性研究[J].药学与临床研究,2014,22(1):20-24.

[10]

Wu P, Ni X, Wang M, et al. Polymorphisms in CYP3A5*3 and MDR1, and haplotype modulate response to plasma levels of tacrolimus in Chinese renal transplant patients[J].Ann Transplant,2011, 16(1):54-60.

[11]

Glowacki F, Lionet A, Buob D, et al. CYP3A5 and ABCB1 polymorphisms in donor and recipient: impact on tacrolimus dose requirements and clinical outcome after renal transplantation[J]. Nephrol Dial Transplant,2011, 26(9):3046-3050.

[12]

Rong G, Jing L Deng L,et al.Influence of CYP3A5 and MDR1(ABCB1) polymorphisms on the pharmacokinetics of tacrolimus in Chinese renal transplant recipients[J]. Transplant Proc,2010, 42(9):3455-3458.

[13]

Cusinato DA, Lacchini R, Romao EA, et al. Relationship of CYP3A5 genotype and ABCB1 diplotype to tacrolimus disposition in Brazilian kidney transplant patients[J]. Br J Clin Pharmacol, 2014, 78(2):364-72.