[1] VISWANATH O, URITS I, BURNS J, et al. Central neuropathic mechanisms in pain signaling pathways: current evidence and recommendations[J]. Adv Ther,2020,37(5):1946-1959. doi:  10.1007/s12325-020-01334-w
[2] GILHUS N E, DEUSCHL G. Neuroinflammation-a common thread in neurological disorders[J]. Nat Rev Neurol,2019,15(8):429-430. doi:  10.1038/s41582-019-0227-8
[3] FRANCHI S, SACERDOTE P, PANERAI A. The prokineticin system: an interface between neural inflammation and pain[J]. Neurol Sci,2017,38(Suppl 1):27-30.
[4] LATTANZI R, MAFTEI D, NEGRI L, et al. PK2β ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through PKR1 receptor[J]. Neuropeptides,2018,71:32-42. doi:  10.1016/j.npep.2018.06.005
[5] LIU Y N, YANG Z, KONG D B, et al. Metformin ameliorates testicular damage in male mice with streptozotocin-induced type 1 diabetes through the PK2/PKR pathway[J]. Oxid Med Cell Longev,2019,2019:5681701.
[6] BASSI I, LUZZANI F, MARELLI F, et al. Knocking-down of the Prokineticin receptor 2 affects reveals its complex role in the regulation of the hypothalamus-pituitary-gonadal axis in the zebrafish model[J]. Sci Rep,2020,10(1):7632. doi:  10.1038/s41598-020-64077-2
[7] REN P, ZHANG H P, QIU F, et al. Prokineticin 2 regulates the electrical activity of rat suprachiasmatic nuclei neurons[J]. PLoS One,2011,6(6):e20263. doi:  10.1371/journal.pone.0020263
[8] ZHAO Y G, WU J Y, WANG X Y, et al. Prokineticins and their G protein-coupled receptors in health and disease[J]. Prog Mol Biol Transl Sci,2019,161:149-179.
[9] ITO H, NODA K, YOSHIDA K, et al. Prokineticin 2 antagonist, PKRA7 suppresses arthritis in mice with collagen-induced arthritis[J]. BMC Musculoskelet Disord,2016,17:387. doi:  10.1186/s12891-016-1243-0
[10] NEGRI L, LATTANZI R. Bv8/PK2 and prokineticin receptors: a druggable pronociceptive system[J]. Curr Opin Pharmacol,2012,12(1):62-66. doi:  10.1016/j.coph.2011.10.023
[11] BOULBERDAA M, URAYAMA K, NEBIGIL C G. Prokineticin receptor 1 (PKR1) signalling in cardiovascular and kidney functions[J]. Cardiovasc Res,2011,92(2):191-198. doi:  10.1093/cvr/cvr228
[12] DORMISHIAN M, TURKERI G, URAYAMA K, et al. Prokineticin receptor-1 is a new regulator of endothelial insulin uptake and capillary formation to control insulin sensitivity and cardiovascular and kidney functions[J]. J Am Heart Assoc,2013,2(5):e000411.
[13] NEGRI L, MAFTEI D. Targeting the prokineticin system to control chronic pain and inflammation[J]. Curr Med Chem,2018,25(32):3883-3894. doi:  10.2174/0929867324666170713102514
[14] VELLANI V, COLUCCI M, LATTANZI R, et al. Sensitization of transient receptor potential vanilloid 1 by the prokineticin receptor agonist Bv8[J]. J Neurosci,2006,26(19):5109-5116. doi:  10.1523/JNEUROSCI.3870-05.2006
[15] NEGRI L, LATTANZI R, GIANNINI E, et al. Nociceptive sensitization by the secretory protein Bv8[J]. Br J Pharmacol,2002,137(8):1147-1154. doi:  10.1038/sj.bjp.0704995
[16] MOLLAY C, WECHSELBERGER C, MIGNOGNA G, et al. Bv8, a small protein from frog skin and its homologue from snake venom induce hyperalgesia in rats[J]. Eur J Pharmacol,1999,374(2):189-196. doi:  10.1016/S0014-2999(99)00229-0
[17] BALBONI G, LAZZARI I, TRAPELLA C, et al. Triazine compounds as antagonists at Bv8-prokineticin receptors[J]. J Med Chem,2008,51(23):7635-7639. doi:  10.1021/jm800854e
[18] NEGRI L, LATTANZI R, GIANNINI E, et al. Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior[J]. J Neurosci,2006,26(25):6716-6727. doi:  10.1523/JNEUROSCI.5403-05.2006
[19] HU W P, ZHANG C K, LI J D, et al. Impaired pain sensation in mice lacking prokineticin 2[J]. Mol Pain,2006,2:35.
[20] MARTUCCI C, FRANCHI S, GIANNINI E, et al. Bv8, the amphibian homologue of the mammalian prokineticins, induces a proinflammatory phenotype of mouse macrophages[J]. Br J Pharmacol,2006,147(2):225-234. doi:  10.1038/sj.bjp.0706467
[21] FRANCHI S, GIANNINI E, LATTUADA D, et al. The prokineticin receptor agonist Bv8 decreases IL-10 and IL-4 production in mice splenocytes by activating prokineticin receptor-1[J]. BMC Immunol,2008,9:60. doi:  10.1186/1471-2172-9-60
[22] MAFTEI D, VELLANI V, ARTICO M, et al. Abnormal pain sensation in mice lacking the prokineticin receptor PKR2: interaction of PKR2 with transient receptor potential TRPV1 and TRPA1[J]. Neuroscience,2020,427:16-28. doi:  10.1016/j.neuroscience.2019.12.003
[23] REN C X, QIU C Y, GAN X, et al. Prokineticin 2 facilitates mechanical allodynia induced by α, β-methylene ATP in rats[J]. Eur J Pharmacol,2015,767:24-29. doi:  10.1016/j.ejphar.2015.09.047
[24] DE FELICE M, MELCHIORRI P, OSSIPOV M H, et al. Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression[J]. Neurosci Lett,2012,521(1):40-45. doi:  10.1016/j.neulet.2012.05.055
[25] NEAL M, LUO J, HARISCHANDRA D S, et al. Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes[J]. Glia,2018,66(10):2137-2157. doi:  10.1002/glia.23467
[26] MAFTEI D, MARCONI V, FLORENZANO F, et al. Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals[J]. Br J Pharmacol,2014,171(21):4850-4865. doi:  10.1111/bph.12793
[27] LATTANZI R, MAFTEI D, MARCONI V, et al. Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining neuropathic pain in the chronic constriction injury model[J]. Biomed Res Int,2015,2015:301292.
[28] GUIDA F, LATTANZI R, BOCCELLA S, et al. PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice[J]. Pharmacol Res,2015,91:36-46. doi:  10.1016/j.phrs.2014.11.004